Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies

Bruce M Coull, D. N. Bourdette, S. H. Goodnight, D. P. Briley, R. Hart

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Antibodies to negatively charged phosholipids including cardiolipin have been recognized in the sera of patients with systemic lupus erythematosus and other disorders. We report 4 patients who experienced cerebral infarctions and dementia in association with anticardiolipin antibodies. These patients did not have the characteristic lupus anticoagulant or systemic lupus erythematosus. The occurrence of anticardiolipin antibodies in patients with multiple cerebral infarctions who do not have evidence of a systemic vasculitis or inflammatory condition suggests that this association may be more common than previously recognized. It may be useful to test for the presence of anticardiolipin antibodies in patients who have unexplained cerebral infarctions.

Original languageEnglish (US)
Pages (from-to)1107-1112
Number of pages6
JournalStroke
Volume18
Issue number6
StatePublished - 1987
Externally publishedYes

Fingerprint

Anticardiolipin Antibodies
Cerebral Infarction
Dementia
Systemic Lupus Erythematosus
Lupus Coagulation Inhibitor
Systemic Vasculitis
Cardiolipins
Antibodies
Serum

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Coull, B. M., Bourdette, D. N., Goodnight, S. H., Briley, D. P., & Hart, R. (1987). Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. Stroke, 18(6), 1107-1112.

Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. / Coull, Bruce M; Bourdette, D. N.; Goodnight, S. H.; Briley, D. P.; Hart, R.

In: Stroke, Vol. 18, No. 6, 1987, p. 1107-1112.

Research output: Contribution to journalArticle

Coull, BM, Bourdette, DN, Goodnight, SH, Briley, DP & Hart, R 1987, 'Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies', Stroke, vol. 18, no. 6, pp. 1107-1112.
Coull BM, Bourdette DN, Goodnight SH, Briley DP, Hart R. Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. Stroke. 1987;18(6):1107-1112.
Coull, Bruce M ; Bourdette, D. N. ; Goodnight, S. H. ; Briley, D. P. ; Hart, R. / Multiple cerebral infarctions and dementia associated with anticardiolipin antibodies. In: Stroke. 1987 ; Vol. 18, No. 6. pp. 1107-1112.
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