Mice carrying the H‐Zb and H‐2s haplotypes are genetically nonresponsive to hen egg‐white lysozyme (HEL). Analysis of the anti‐HEL response patterns of F1, F2 and backcross progeny showed that responsiveness was dominant and H‐2‐linked. From plaque‐forming cell and serum assays in intra‐H‐2 recombinant mice, it was established that two I loci were implicated, the possession of either leading to responsiveness to HEL. One of the I genes maps in I‐A, and the second in I‐C, S or G. While the nonresponse phenotype was determined by the H‐2 haplotype, there were codominant non‐H‐2 genes which contributed to a severe reduction in the level of antibody produced in responder strains. A model is presented attributing the outcome of an encounter with HEL to the regulatory balance of helper and suppressor T cells, which have been activated by different subregions of the major histocompatibility complex.
ASJC Scopus subject areas
- Immunology and Allergy