Multiple opiate receptors on neurons of the mammalian central nervous system. In vivo and in vitro studies

W. Zieglgänsberger, Edward D French, N. Mercuri, F. Pelayo, J. T. Williams

Research output: Contribution to journalArticle

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Abstract

Experiments were performed in rat spinal cord cells in vivo and on hippocampal pyramidal cells in vitro. These investigations suggest that acute and chronic treatment renders the neurons subsensitive to opiate alkaloids without altering their sensitivity to opioid peptides. The experiments performed in the dorsal horn of the spinal cord provide evidence that in this structure mu- and delta-receptors may also be localized on the same cell. The evidence for the existence of distinct types of opiate receptors as originally proposed by (1) and suggested by the differing pattern of opiate and opioid peptide activity in various assay systems has been substantiated by investigations involving the selective development of tolerance and the protection of a particular receptor subtype by chemical manipulation. Furthermore, they have been characterized by the use of low concentrations of radio-labelled agonists and antagonists and through the ability of GTP to influence differentially their binding to the opiate receptor (for refs. see: 2). Recently autoradiographic techniques were able to provide direct evidence by mu- and delta-receptors in the mammalian brain (3; 4; 5; 6; and cits. therein). The presence of multiple opiate receptors located on the same cell is suggested by the present study.

Original languageEnglish (US)
Pages (from-to)2343-2346
Number of pages4
JournalLife Sciences
Volume31
Issue number20-21
DOIs
StatePublished - 1982
Externally publishedYes

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Opioid Peptides
Neurology
Opioid Receptors
Neurons
delta Opioid Receptor
Central Nervous System
mu Opioid Receptor
Opiate Alkaloids
Pyramidal Cells
Guanosine Triphosphate
Radio
Rats
Assays
Brain
Spinal Cord
Experiments
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology

Cite this

Multiple opiate receptors on neurons of the mammalian central nervous system. In vivo and in vitro studies. / Zieglgänsberger, W.; French, Edward D; Mercuri, N.; Pelayo, F.; Williams, J. T.

In: Life Sciences, Vol. 31, No. 20-21, 1982, p. 2343-2346.

Research output: Contribution to journalArticle

Zieglgänsberger, W. ; French, Edward D ; Mercuri, N. ; Pelayo, F. ; Williams, J. T. / Multiple opiate receptors on neurons of the mammalian central nervous system. In vivo and in vitro studies. In: Life Sciences. 1982 ; Vol. 31, No. 20-21. pp. 2343-2346.
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