Multislice CEST MRI improves the spatial assessment of tumor pH

Edward A. Randtke, Jeffry C. Granados, Christine M. Howison, Mark "Marty" Pagel, Julio Cárdenas-Rodríguez

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Multislice maps of extracellular pH (pHe) are needed to interrogate the heterogeneities of tumors and normal organs. To address this need, we have developed a multislice chemical exchange saturation transfer (CEST) MRI acquisition method with a CEST spectrum-fitting method that measures in vivo pHe over a range of 6.3 to 7.4. Methods: The phase offset multiplanar (POMP) method was adapted for CEST fast imaging with steady-state free precession (FISP) MRI to acquire multiple image slices with a single CEST saturation pulse. The Bloch-McConnell equations were modified to include pH based on a calibration of pH and chemical exchange rate for the contrast agent iopamidol. These equations were used to estimate the pixel-wise pHe values throughout the multislice acidoCEST MR images of the tumor, kidney, bladder, and other tissues of a MDA-MB-231 tumor model. Results: Multislice acidoCEST MRI successfully mapped a gradient of pHe from 6.73 to 6.81 units from the tumor core to rim, and also mapped a gradient of pHe 6.56 to 6.97 across the mouse kidney. The bladder was found to be pHe 6.3. Conclusion: AcidoCEST MRI with POMP acquisition and Bloch-McConnel analysis can map pHe in multiple imaging slices through the tumor, kidney, and bladder. This multislice evaluation facilitates assessments of spatial heterogeneity of tissue pHe.

Original languageEnglish (US)
JournalMagnetic Resonance in Medicine
DOIs
StateAccepted/In press - 2016

Fingerprint

Kidney
Urinary Bladder Neoplasms
Neoplasms
Iopamidol
Contrast Media
Calibration
Urinary Bladder
Magnetic Resonance Imaging

Keywords

  • CEST MRI
  • CEST-FISP
  • Extracellular pH
  • Iopamidol
  • POMP MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Randtke, E. A., Granados, J. C., Howison, C. M., Pagel, M. M., & Cárdenas-Rodríguez, J. (Accepted/In press). Multislice CEST MRI improves the spatial assessment of tumor pH. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.26348

Multislice CEST MRI improves the spatial assessment of tumor pH. / Randtke, Edward A.; Granados, Jeffry C.; Howison, Christine M.; Pagel, Mark "Marty"; Cárdenas-Rodríguez, Julio.

In: Magnetic Resonance in Medicine, 2016.

Research output: Contribution to journalArticle

Randtke, Edward A. ; Granados, Jeffry C. ; Howison, Christine M. ; Pagel, Mark "Marty" ; Cárdenas-Rodríguez, Julio. / Multislice CEST MRI improves the spatial assessment of tumor pH. In: Magnetic Resonance in Medicine. 2016.
@article{fc152b99a05e44898bf5d8b2ae3f7cee,
title = "Multislice CEST MRI improves the spatial assessment of tumor pH",
abstract = "Purpose: Multislice maps of extracellular pH (pHe) are needed to interrogate the heterogeneities of tumors and normal organs. To address this need, we have developed a multislice chemical exchange saturation transfer (CEST) MRI acquisition method with a CEST spectrum-fitting method that measures in vivo pHe over a range of 6.3 to 7.4. Methods: The phase offset multiplanar (POMP) method was adapted for CEST fast imaging with steady-state free precession (FISP) MRI to acquire multiple image slices with a single CEST saturation pulse. The Bloch-McConnell equations were modified to include pH based on a calibration of pH and chemical exchange rate for the contrast agent iopamidol. These equations were used to estimate the pixel-wise pHe values throughout the multislice acidoCEST MR images of the tumor, kidney, bladder, and other tissues of a MDA-MB-231 tumor model. Results: Multislice acidoCEST MRI successfully mapped a gradient of pHe from 6.73 to 6.81 units from the tumor core to rim, and also mapped a gradient of pHe 6.56 to 6.97 across the mouse kidney. The bladder was found to be pHe 6.3. Conclusion: AcidoCEST MRI with POMP acquisition and Bloch-McConnel analysis can map pHe in multiple imaging slices through the tumor, kidney, and bladder. This multislice evaluation facilitates assessments of spatial heterogeneity of tissue pHe.",
keywords = "CEST MRI, CEST-FISP, Extracellular pH, Iopamidol, POMP MRI",
author = "Randtke, {Edward A.} and Granados, {Jeffry C.} and Howison, {Christine M.} and Pagel, {Mark {"}Marty{"}} and Julio C{\'a}rdenas-Rodr{\'i}guez",
year = "2016",
doi = "10.1002/mrm.26348",
language = "English (US)",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Multislice CEST MRI improves the spatial assessment of tumor pH

AU - Randtke, Edward A.

AU - Granados, Jeffry C.

AU - Howison, Christine M.

AU - Pagel, Mark "Marty"

AU - Cárdenas-Rodríguez, Julio

PY - 2016

Y1 - 2016

N2 - Purpose: Multislice maps of extracellular pH (pHe) are needed to interrogate the heterogeneities of tumors and normal organs. To address this need, we have developed a multislice chemical exchange saturation transfer (CEST) MRI acquisition method with a CEST spectrum-fitting method that measures in vivo pHe over a range of 6.3 to 7.4. Methods: The phase offset multiplanar (POMP) method was adapted for CEST fast imaging with steady-state free precession (FISP) MRI to acquire multiple image slices with a single CEST saturation pulse. The Bloch-McConnell equations were modified to include pH based on a calibration of pH and chemical exchange rate for the contrast agent iopamidol. These equations were used to estimate the pixel-wise pHe values throughout the multislice acidoCEST MR images of the tumor, kidney, bladder, and other tissues of a MDA-MB-231 tumor model. Results: Multislice acidoCEST MRI successfully mapped a gradient of pHe from 6.73 to 6.81 units from the tumor core to rim, and also mapped a gradient of pHe 6.56 to 6.97 across the mouse kidney. The bladder was found to be pHe 6.3. Conclusion: AcidoCEST MRI with POMP acquisition and Bloch-McConnel analysis can map pHe in multiple imaging slices through the tumor, kidney, and bladder. This multislice evaluation facilitates assessments of spatial heterogeneity of tissue pHe.

AB - Purpose: Multislice maps of extracellular pH (pHe) are needed to interrogate the heterogeneities of tumors and normal organs. To address this need, we have developed a multislice chemical exchange saturation transfer (CEST) MRI acquisition method with a CEST spectrum-fitting method that measures in vivo pHe over a range of 6.3 to 7.4. Methods: The phase offset multiplanar (POMP) method was adapted for CEST fast imaging with steady-state free precession (FISP) MRI to acquire multiple image slices with a single CEST saturation pulse. The Bloch-McConnell equations were modified to include pH based on a calibration of pH and chemical exchange rate for the contrast agent iopamidol. These equations were used to estimate the pixel-wise pHe values throughout the multislice acidoCEST MR images of the tumor, kidney, bladder, and other tissues of a MDA-MB-231 tumor model. Results: Multislice acidoCEST MRI successfully mapped a gradient of pHe from 6.73 to 6.81 units from the tumor core to rim, and also mapped a gradient of pHe 6.56 to 6.97 across the mouse kidney. The bladder was found to be pHe 6.3. Conclusion: AcidoCEST MRI with POMP acquisition and Bloch-McConnel analysis can map pHe in multiple imaging slices through the tumor, kidney, and bladder. This multislice evaluation facilitates assessments of spatial heterogeneity of tissue pHe.

KW - CEST MRI

KW - CEST-FISP

KW - Extracellular pH

KW - Iopamidol

KW - POMP MRI

UR - http://www.scopus.com/inward/record.url?scp=84979738506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979738506&partnerID=8YFLogxK

U2 - 10.1002/mrm.26348

DO - 10.1002/mrm.26348

M3 - Article

C2 - 27465207

AN - SCOPUS:84979738506

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

ER -