Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The current opioid crisis has created a tragic problem in medicine and society. Pain is the most ubiquitous and costly disease in society and yet all of our “treatments” have toxicities, especially for prolonged use. However, there are several alternatives that have been discovered in the past fifteen years that have been demonstrated in animals to have none of the toxicities of current drugs. Many of the compounds are multivalent and have novel biological activity profiles. Unfortunately, none of these have been in clinical trials in humans, perhaps because they were discovered in academic laboratories. A review of these novel chemicals are given in this paper.

Original languageEnglish (US)
Pages (from-to)63-67
Number of pages5
JournalPeptides
Volume116
DOIs
StatePublished - Jun 1 2019

Fingerprint

Peptidomimetics
Toxicity
Ligands
Pain
Peptides
Bioactivity
Drug-Related Side Effects and Adverse Reactions
Opioid Analgesics
Medicine
Animals
Clinical Trials
Therapeutics
Pharmaceutical Preparations

Keywords

  • Agonists
  • Novel peptide structures
  • Opioid ligands
  • Opioid receptors
  • Receptor
  • Selectivity

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Multivalent peptide and peptidomimetic ligands for the treatment of pain without toxicities and addiction. / Hruby, Victor J.

In: Peptides, Vol. 116, 01.06.2019, p. 63-67.

Research output: Contribution to journalReview article

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