Muramyl dipeptide: Not just another brick in the wall

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The robust expression of microbial pattern recognition receptors such as TLR4 and Nod2 in intestinal stem cells reflects an active communication dynamic between the host and the gut microbiota. A new study reveals that muramyl dipeptide, the bacterial cell wall peptidoglycan motif, activates Nod2 within crypt base columnar Lgr5-positive stem cells and promotes their survival. Apart from the immediate relevance to the growth of organoids for in vitro experiments, the study raises new questions about the molecular mechanisms whereby gut microbes influence intestinal physiology.

Original languageEnglish (US)
JournalGut microbes
Volume5
Issue number3
DOIs
StatePublished - 2014

Keywords

  • Lgr5
  • Muramyl dipeptide
  • Nod2
  • Organoids
  • Stem cells

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

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