Muscarinic cholinergic receptor heterogeneity

Frederick J. Ehlert, William R. Roeske, Henry I. Yamamura

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

The relatively recent application of receptor binding techniques to muscarinic receptor pharmacology has provided new data that generally confirm classical ideas about agonist-receptor interactions and competitive antagonism. However, additional information regarding muscarinic receptor heterogeneity has been provided through [3H]ligand binding studies which might not have been anticipated from the results of whole tissue experiments. Ultimately, isolation and identification of the muscarinic receptor and the effector systems with which the receptor is coupled will provide a better understanding of the significance of muscarinic receptor heterogeneity.

Original languageEnglish (US)
Pages (from-to)336-339
Number of pages4
JournalTrends in Neurosciences
Volume5
Issue numberC
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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