Mutagenic and Recombinogenic Effects of the Antitumor Antibiotic Anthramycin

Mohammed A. Hannan, Laurence H. Hurley, Chandrachuranand Gairola

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Anthramycin, one of the pyrrolo(1,4)benzodiazepine antibiotics with potent antitumor activity, was tested for its effects on a number of genetic parameters. The results show that this antibiotic is nonmutagenic in the Ames strains of Salmonella typhimurium while mutagenic in only one and antimutagenic in the rest of the genes tested in the eukaryotic organism Saccharomyces cerevisiae. The antibiotic is, however, a potent recombinogen inasmuch as it induced mitotic crossing over, mitotic gene conversion, and possibly other chromosomal alterations in a diploid strain of S. cerevisiae. These studies emphasize the need for a battery of test systems including eukaryotic organisms to detect the genetic activity of certain antitumor drugs. The importance of considering data distinguishing between highly mutagenic and poorly mutagenic cancer chemotherapeutic agents is also discussed.

Original languageEnglish (US)
Pages (from-to)2795-2799
Number of pages5
JournalCancer Research
Volume38
Issue number9
StatePublished - Sep 1978
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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