Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194

Humberto E. Ortega, Paul R. Graupner, Yumi Asai, Karen Tendyke, Dayong Qiu, Young Yongchun Shen, Nivia Rios, A. Elizabeth Arnold, Phyllis D. Coley, Thomas A. Kursar, William H. Gerwick, Luis Cubilla-Rios

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Two novel reddish-orange alkaloids, mycoleptodiscin A (1) and mycoleptodiscin B (2), were isolated from liquid cultures of the endophytic fungus Mycoleptodiscus sp. that had been isolated from Desmotes incomparabilis in Panama. Elucidation of their structures was accomplished using 1D and 2D NMR spectroscopy in combination with IR spectroscopic and MS data. These compounds are indole-terpenes with a new skeleton uncommon in nature. Mycoleptodiscin B (2) was active in inhibiting the growth of cancer cell lines with IC 50 values in the range 0.60-0.78 μM.

Original languageEnglish (US)
Pages (from-to)741-744
Number of pages4
JournalJournal Of Natural Products
Volume76
Issue number4
DOIs
StatePublished - Apr 26 2013

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Ortega, H. E., Graupner, P. R., Asai, Y., Tendyke, K., Qiu, D., Shen, Y. Y., Rios, N., Arnold, A. E., Coley, P. D., Kursar, T. A., Gerwick, W. H., & Cubilla-Rios, L. (2013). Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194. Journal Of Natural Products, 76(4), 741-744. https://doi.org/10.1021/np300792t