Mycotoxins and antifungal drug interactions: Implications in the treatment of illnesses due to indoor chronic toxigenic mold exposures

Ebere C. Anyanwu, Andrew W. Campbell, John E. Ehiri

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Chronic exposure to toxigenic molds in water-damaged buildings is an indoor environmental health problem to which escalating health and property insurance costs are raising a statewide concern in recent times. This paper reviews the structural and functional properties of mycotoxins produced by toxigenic molds and their interactive health implications with antifungal drugs. Fundamental bases of pathophysiological, neurodevelopmental, and cellular mechanisms of mycotoxic effects are evaluated. It is most likely that the interactions of mycotoxins with antifungal drugs may, at least in part, contribute to the observable persistent illnesses, antifungal drug resistance, and allergic reactions in patients exposed to chronic toxigenic molds. Safe dose level of mycotoxin in humans is not clear. Hence, the safety regulations in place at the moment remain inconclusive, precautionary, and arbitrary. Since some of the antifungal drugs are derived from molds, and since they have structural and functional groups similar to those of mycotoxins, the knowledge of their interactions are important in enhancing preventive measures.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalScientific World Journal
Volume4
DOIs
StatePublished - 2004

Keywords

  • Antifungal drugs
  • Mycotoxins
  • Toxigenic molds
  • Water-damaged buildings

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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