Myelomonocytic antigen positive multiple myeloma

T. M. Grogan, B. G M Durie, Catherine S Perry, L. Richter, E. Vela

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

In a four year span, between 1983 and 1987, 215 bone marrow and cell culture samples from 125 myeloma patients were immunotyped and coexpression of myelomonocytic and plasma cell antigens occurred in 16 (13%). We employed both immunohistochemical and flow cytometry methods including coplots and double labelling. Three types of myeloma cases were found: (1) those with isolated myeloid antigen coexpression, usually Leu M1 or esterase (BE, CE) positive (11 cases); (2) those with multiple myeloid antigens (Leu M1, M3, M5, MY7, BE, CE) (four cases); and (3) one case beginning as 1 and ending as 2. Isolated myeloid antigen expression was generally associated with typical features of myeloma with survival close to the anticipated median (33 months), while multiple myeloid antigen expression was associated with more aggressive disease and shorter survival duration (median survival 16 months). The latter subgroup also had other poor prognosis factors including high labelling index and common acute lymphoblastic leukemia antigen (CALLA) positivity. Other features found overall were frequent abnormal karyotypes (seven of 12 abnormal) and coexpressed IgA (eight of 16); all IgA+ cases also coexpressed Leu M1. We conclude that there is an unusual and unexpected predilection for coexpression of myelomonocytic antigens in myeloma cells. The reasons are not immediately obvious. Whether the coexpression indicates the myeloma cells truly have latent multilineage potential or just aberrantly coexpress other hematopoietic antigen as a manifestation of malignancy remains to be explained. However, a cell line established from the bone marrow of one patient is a valuable scientific tool allowing detailed analysis of these questions.

Original languageEnglish (US)
Pages (from-to)763-769
Number of pages7
JournalBlood
Volume73
Issue number3
StatePublished - 1989

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Multiple Myeloma
Antigens
Immunoglobulin A
Labeling
Survival
Bone
CD15 Antigens
Abnormal Karyotype
Neprilysin
Flow cytometry
Esterases
Plasma Cells
Cell culture
Bone Marrow Cells
Flow Cytometry
Cell Culture Techniques
Bone Marrow
Cells
Plasmas
Cell Line

ASJC Scopus subject areas

  • Hematology

Cite this

Grogan, T. M., Durie, B. G. M., Perry, C. S., Richter, L., & Vela, E. (1989). Myelomonocytic antigen positive multiple myeloma. Blood, 73(3), 763-769.

Myelomonocytic antigen positive multiple myeloma. / Grogan, T. M.; Durie, B. G M; Perry, Catherine S; Richter, L.; Vela, E.

In: Blood, Vol. 73, No. 3, 1989, p. 763-769.

Research output: Contribution to journalArticle

Grogan, TM, Durie, BGM, Perry, CS, Richter, L & Vela, E 1989, 'Myelomonocytic antigen positive multiple myeloma', Blood, vol. 73, no. 3, pp. 763-769.
Grogan TM, Durie BGM, Perry CS, Richter L, Vela E. Myelomonocytic antigen positive multiple myeloma. Blood. 1989;73(3):763-769.
Grogan, T. M. ; Durie, B. G M ; Perry, Catherine S ; Richter, L. ; Vela, E. / Myelomonocytic antigen positive multiple myeloma. In: Blood. 1989 ; Vol. 73, No. 3. pp. 763-769.
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