Myelomonocytic myeloma cell line (LB84-1)

B. G M Durie, T. M. Grogan, Catherine S Perry, E. Vela, V. Baum, M. A. Rodriquez, Y. Frutiger

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A human cell line (LB 84-1) has been established from the bone marrow of a patient with Bence-Jones myeloma. Coexpression of plasma cell (Leu 17[CD38]) and myelomonocytic antigens (Leu MI[CD15], Leu M5 (CD11c], MY7 [CD13] plus butyrate and chloracetate esterase) proved to be an unusual but sustained feature of this cell line. The plasma cell phenotype with multinuclearity was retained. Shared major chromosomal abnormalities (del [5] [p14], t[5;?] [q35;?], del [6] [q21], and del 7[q32]) between the direct and cell line karyotypes affirmed the LB 84-1 cell as being derived from the original patient myeloma clone. The mechanisms potentially responsible for the aberrant coexpressed phenotype are discussed. This myelomonocytic myeloma cell line will hopefully prove to be a valuable tool for the study of the genotypic and phenotypic evolution of human myeloma.

Original languageEnglish (US)
Pages (from-to)770-776
Number of pages7
JournalBlood
Volume73
Issue number3
StatePublished - 1989

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Cells
Cell Line
Plasma Cells
CD38 Antigens
Phenotype
Plasmas
Differentiation Antigens
Karyotype
Chromosome Aberrations
Bone
Clone Cells
Bone Marrow

ASJC Scopus subject areas

  • Hematology

Cite this

Durie, B. G. M., Grogan, T. M., Perry, C. S., Vela, E., Baum, V., Rodriquez, M. A., & Frutiger, Y. (1989). Myelomonocytic myeloma cell line (LB84-1). Blood, 73(3), 770-776.

Myelomonocytic myeloma cell line (LB84-1). / Durie, B. G M; Grogan, T. M.; Perry, Catherine S; Vela, E.; Baum, V.; Rodriquez, M. A.; Frutiger, Y.

In: Blood, Vol. 73, No. 3, 1989, p. 770-776.

Research output: Contribution to journalArticle

Durie, BGM, Grogan, TM, Perry, CS, Vela, E, Baum, V, Rodriquez, MA & Frutiger, Y 1989, 'Myelomonocytic myeloma cell line (LB84-1)', Blood, vol. 73, no. 3, pp. 770-776.
Durie BGM, Grogan TM, Perry CS, Vela E, Baum V, Rodriquez MA et al. Myelomonocytic myeloma cell line (LB84-1). Blood. 1989;73(3):770-776.
Durie, B. G M ; Grogan, T. M. ; Perry, Catherine S ; Vela, E. ; Baum, V. ; Rodriquez, M. A. ; Frutiger, Y. / Myelomonocytic myeloma cell line (LB84-1). In: Blood. 1989 ; Vol. 73, No. 3. pp. 770-776.
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AU - Durie, B. G M

AU - Grogan, T. M.

AU - Perry, Catherine S

AU - Vela, E.

AU - Baum, V.

AU - Rodriquez, M. A.

AU - Frutiger, Y.

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N2 - A human cell line (LB 84-1) has been established from the bone marrow of a patient with Bence-Jones myeloma. Coexpression of plasma cell (Leu 17[CD38]) and myelomonocytic antigens (Leu MI[CD15], Leu M5 (CD11c], MY7 [CD13] plus butyrate and chloracetate esterase) proved to be an unusual but sustained feature of this cell line. The plasma cell phenotype with multinuclearity was retained. Shared major chromosomal abnormalities (del [5] [p14], t[5;?] [q35;?], del [6] [q21], and del 7[q32]) between the direct and cell line karyotypes affirmed the LB 84-1 cell as being derived from the original patient myeloma clone. The mechanisms potentially responsible for the aberrant coexpressed phenotype are discussed. This myelomonocytic myeloma cell line will hopefully prove to be a valuable tool for the study of the genotypic and phenotypic evolution of human myeloma.

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