Nabilone: A potent antiemetic cannabinol with minimal euphoria

T. S. Herman, S. E. Jones, J. Dean, S. Leigh, R. Dorr, T. E. Moon, S. E. Salmon

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals. We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in 10 of 13 patients who were refractory to conventional antiemetics. A dose-response effect was apparent. The drug was generally well-tolerated, although it also had sedative effects. Additionally, dizziness, decreased coordination and postural hypotension were observed in some patients. Euphoric effects of the agent were minimal at antiemetic dosage levels.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalBiomedicine Express
Volume27
Issue number9-10
StatePublished - Dec 1 1977

ASJC Scopus subject areas

  • Medicine(all)

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    Herman, T. S., Jones, S. E., Dean, J., Leigh, S., Dorr, R., Moon, T. E., & Salmon, S. E. (1977). Nabilone: A potent antiemetic cannabinol with minimal euphoria. Biomedicine Express, 27(9-10), 331-334.