Nabilone: A potent antiemetic cannabinol with minimal euphoria

T. S. Herman, S. E. Jones, J. Dean, S. Leigh, Robert T Dorr, T. E. Moon, S. E. Salmon

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Nabilone is a cannabinol derivative which has potent central antiemetic effects in animals. We observed that the drug significantly reduced the nausea and vomiting induced by cancer chemotherapy in 10 of 13 patients who were refractory to conventional antiemetics. A dose-response effect was apparent. The drug was generally well-tolerated, although it also had sedative effects. Additionally, dizziness, decreased coordination and postural hypotension were observed in some patients. Euphoric effects of the agent were minimal at antiemetic dosage levels.

Original languageEnglish (US)
Pages (from-to)331-334
Number of pages4
JournalBiomedicine Express
Volume27
Issue number9-10
StatePublished - 1977
Externally publishedYes

Fingerprint

Cannabinol
Antiemetics
Orthostatic Hypotension
Dizziness
Hypnotics and Sedatives
Pharmaceutical Preparations
Nausea
Vomiting
Drug Therapy
nabilone
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Herman, T. S., Jones, S. E., Dean, J., Leigh, S., Dorr, R. T., Moon, T. E., & Salmon, S. E. (1977). Nabilone: A potent antiemetic cannabinol with minimal euphoria. Biomedicine Express, 27(9-10), 331-334.

Nabilone : A potent antiemetic cannabinol with minimal euphoria. / Herman, T. S.; Jones, S. E.; Dean, J.; Leigh, S.; Dorr, Robert T; Moon, T. E.; Salmon, S. E.

In: Biomedicine Express, Vol. 27, No. 9-10, 1977, p. 331-334.

Research output: Contribution to journalArticle

Herman, TS, Jones, SE, Dean, J, Leigh, S, Dorr, RT, Moon, TE & Salmon, SE 1977, 'Nabilone: A potent antiemetic cannabinol with minimal euphoria', Biomedicine Express, vol. 27, no. 9-10, pp. 331-334.
Herman TS, Jones SE, Dean J, Leigh S, Dorr RT, Moon TE et al. Nabilone: A potent antiemetic cannabinol with minimal euphoria. Biomedicine Express. 1977;27(9-10):331-334.
Herman, T. S. ; Jones, S. E. ; Dean, J. ; Leigh, S. ; Dorr, Robert T ; Moon, T. E. ; Salmon, S. E. / Nabilone : A potent antiemetic cannabinol with minimal euphoria. In: Biomedicine Express. 1977 ; Vol. 27, No. 9-10. pp. 331-334.
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