Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation

Larry D. Reid, Christopher L. Hubbell, Matthew B. Glaccum, Edward J. Bilsky, Philip S. Portoghese, Frank Porreca

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Recent experimental results have led to the suggestion that opioid antagonists can modulate the reinforcing properties of cocaine. In this experiment, rats were fixed with chronically indwelling bipolar electrodes for stimulation of the medial forebrain bundle (MFB) as it courses through the hypothalamus. Rats were taught to press a lever for brief trains of electrical stimulation of the MFB. Subsequently, they were allowed to press for varying intensities of stimulation daily until their response rates were stable. Cocaine (5 mg/kg, s.c.) enhanced the rate of pressing for lower intensities of brain stimulation. Naltrindole (3 mg/kg, i.p.) had no effect on response rate alone but blocked the cocaine-induced facilitation of pressing for rewarding brain stimulation. An implication that can be drawn from these data is that naltrindole, or other delta-selective opioid antagonists, might be effective as medicines for use in treating cocaine abuse.

Original languageEnglish (US)
JournalLife Sciences
Volume52
Issue number9
DOIs
StatePublished - 1993

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naltrindole
delta Opioid Receptor
Narcotic Antagonists
Cocaine
Medial Forebrain Bundle
Brain
Rats
Cocaine-Related Disorders
Electric Stimulation
Hypothalamus
Electrodes
Medicine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation. / Reid, Larry D.; Hubbell, Christopher L.; Glaccum, Matthew B.; Bilsky, Edward J.; Portoghese, Philip S.; Porreca, Frank.

In: Life Sciences, Vol. 52, No. 9, 1993.

Research output: Contribution to journalArticle

Reid, Larry D. ; Hubbell, Christopher L. ; Glaccum, Matthew B. ; Bilsky, Edward J. ; Portoghese, Philip S. ; Porreca, Frank. / Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation. In: Life Sciences. 1993 ; Vol. 52, No. 9.
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