Nanoengineered platforms for cancer chemoprevention

Vinay Gidwani, Yi Lu, Donna Zhang, Pak Kin Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The ingestion of some organic compounds has been known to lower the risk of cancer. With emerging studies in the past decade, the biological effect of these compounds has been recognized within a clinical context and presents an appealing strategy for cancer prevention. These compounds, now commonly referred as chemopreventive agents or anticarcinogens, often exert their activity by inducing expression of phase II enzymes and endogenous antioxidants via the Nrf2 signaling pathway, which defends cells from harmful oxidative stress and reactive carcinogenic intermediates. Here, we present several micro- and nanoscale technological modularities, including two molecular assays and a multiplexed microOuidic device, toward the creation of a nanoengineered platform for high-throughput screening of chemopreventive compounds targeting Nrf2. The ability to rapidly identify agents that can prevent the occurrence and reduce the severity of cancer is of great importance in the management of cancer and represents a pathway toward the realization of preventive medicine.

Original languageEnglish (US)
Title of host publication4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
Pages832-836
Number of pages5
DOIs
StatePublished - 2009
Event4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 - Shenzhen, China
Duration: Jan 5 2009Jan 8 2009

Other

Other4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009
CountryChina
CityShenzhen
Period1/5/091/8/09

Fingerprint

Oxidative stress
Antioxidants
Organic compounds
Medicine
Assays
Screening
Enzymes
Throughput
Chemoprevention

Keywords

  • Cancer
  • Chemoprevention
  • Drug screening
  • Molecular sensors
  • Nrj2

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Gidwani, V., Lu, Y., Zhang, D., & Wong, P. K. (2009). Nanoengineered platforms for cancer chemoprevention. In 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009 (pp. 832-836). [5068705] https://doi.org/10.1109/NEMS.2009.5068705

Nanoengineered platforms for cancer chemoprevention. / Gidwani, Vinay; Lu, Yi; Zhang, Donna; Wong, Pak Kin.

4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009. 2009. p. 832-836 5068705.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gidwani, V, Lu, Y, Zhang, D & Wong, PK 2009, Nanoengineered platforms for cancer chemoprevention. in 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009., 5068705, pp. 832-836, 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009, Shenzhen, China, 1/5/09. https://doi.org/10.1109/NEMS.2009.5068705
Gidwani V, Lu Y, Zhang D, Wong PK. Nanoengineered platforms for cancer chemoprevention. In 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009. 2009. p. 832-836. 5068705 https://doi.org/10.1109/NEMS.2009.5068705
Gidwani, Vinay ; Lu, Yi ; Zhang, Donna ; Wong, Pak Kin. / Nanoengineered platforms for cancer chemoprevention. 4th IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2009. 2009. pp. 832-836
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