Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells

Zhengbao Zha, Celine Cohn, Zhifei Dai, Weiguo Qiu, Jinhong Zhang, Xiaoyi Wu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Polymerizable cholesteryl-succinyl silane was synthesized and fabricated into stable nanofibrous lipid membranes using a combined sol-gel and electrospinning process. The resulting nanofibrous lipid membranes are capable of functionally immobilizing membrane proteins such as antibodies, thereby enabling targeted cell capture via the antigen-antibody interactions.

Original languageEnglish (US)
Pages (from-to)3435-3440
Number of pages6
JournalAdvanced Materials
Volume23
Issue number30
DOIs
StatePublished - Aug 9 2011

Fingerprint

Membrane Lipids
Antibodies
Silanes
Electrospinning
Antigens
Sol-gels
Membrane Proteins
Proteins
Membranes

Keywords

  • antibody immobilization
  • cell capture
  • cholesterol
  • Lipid nanofibers

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells. / Zha, Zhengbao; Cohn, Celine; Dai, Zhifei; Qiu, Weiguo; Zhang, Jinhong; Wu, Xiaoyi.

In: Advanced Materials, Vol. 23, No. 30, 09.08.2011, p. 3435-3440.

Research output: Contribution to journalArticle

Zha, Zhengbao ; Cohn, Celine ; Dai, Zhifei ; Qiu, Weiguo ; Zhang, Jinhong ; Wu, Xiaoyi. / Nanofibrous lipid membranes capable of functionally immobilizing antibodies and capturing specific cells. In: Advanced Materials. 2011 ; Vol. 23, No. 30. pp. 3435-3440.
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