Nanofluidic sieves for DNA separation using colloidal crystal technology

L. S.L. Cheung, K. P. Gerhardt, M. J. Wirth, Y. Zohar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The fabrication of a novel nanosphere electrophoresis (NEP) microchip designed for DNA separation is described. A colloidal crystal technology, augmented by surface micromachining techniques, is utilized for patterning nanosphere-coated regions in microchannels to serve as an artificial sieving matrix. Fast and clear separation of DNA ladder is demonstrated a NEP device; furthermore, nanosphere-size dependent stacking effect and electrophoresis mobility are discussed.

Original languageEnglish (US)
Title of host publicationProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
EditorsJean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
PublisherChemical and Biological Microsystems Society
Pages1586-1588
Number of pages3
ISBN (Electronic)9780979806407
StatePublished - 2007
Event11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France
Duration: Oct 7 2007Oct 11 2007

Publication series

NameProceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
CountryFrance
CityParis
Period10/7/0710/11/07

Keywords

  • Colloidal self-assembly
  • DNA separation
  • Electrophoresis
  • Nanofluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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  • Cite this

    Cheung, L. S. L., Gerhardt, K. P., Wirth, M. J., & Zohar, Y. (2007). Nanofluidic sieves for DNA separation using colloidal crystal technology. In J-L. Viovy, P. Tabeling, S. Descroix, & L. Malaquin (Eds.), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 (pp. 1586-1588). (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007). Chemical and Biological Microsystems Society.