Abstract
We report our fabrication of nanoscale devices using electron beam and nanoimprint lithography (NIL). We focus our study in the emerging fields of NIL, nanophotonics and nanobiotechnology and give a few examples as to how these nanodevices may be applied toward genomic and proteomic applications for molecular analysis. The examples include reverse NIL-fabricated nanofluidic channels for DNA stretching, nanoscale molecular traps constructed from dielectric constrictions for DNA or protein focusing by dielectrophoresis, multi-layer nanoburger and nanoburger multiplets for optimized surface-plasma enhanced Raman scattering for protein detection, and biomolecular motor-based nanosystems. The development of advanced nanopatterning techniques promises reliable and high-throughput manufacturing of nanodevices which could impact significantly on the areas of genomics, proteomics, drug discovery and molecular clinical diagnostics.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
| Editors | W.Y.-C. Lai, S. Pau, O.D. Lopez |
| Pages | 183-192 |
| Number of pages | 10 |
| Volume | 5592 |
| DOIs | |
| State | Published - 2005 |
| Event | Nanofabrication: Technologies, Devices, and Applications - Philadelphia, PA, United States Duration: Oct 25 2004 → Oct 28 2004 |
Other
| Other | Nanofabrication: Technologies, Devices, and Applications |
|---|---|
| Country | United States |
| City | Philadelphia, PA |
| Period | 10/25/04 → 10/28/04 |
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Keywords
- Biomotors
- Biosensors
- Dielectrophoresis
- Genomics
- Nanofabrication
- Nanofluidics
- Nanoimprint lithography
- Nanophotonics
- Proteomics
- SERS
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics
Cite this
Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications. / Chou, Chia Fu; Gu, Jian; Wei, Qihuo; Liu, Yingjie; Gupta, Ravi; Nishio, Takeyoshi; Zenhausern, Frederic.
Proceedings of SPIE - The International Society for Optical Engineering. ed. / W.Y.-C. Lai; S. Pau; O.D. Lopez. Vol. 5592 2005. p. 183-192 35.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications
AU - Chou, Chia Fu
AU - Gu, Jian
AU - Wei, Qihuo
AU - Liu, Yingjie
AU - Gupta, Ravi
AU - Nishio, Takeyoshi
AU - Zenhausern, Frederic
PY - 2005
Y1 - 2005
N2 - We report our fabrication of nanoscale devices using electron beam and nanoimprint lithography (NIL). We focus our study in the emerging fields of NIL, nanophotonics and nanobiotechnology and give a few examples as to how these nanodevices may be applied toward genomic and proteomic applications for molecular analysis. The examples include reverse NIL-fabricated nanofluidic channels for DNA stretching, nanoscale molecular traps constructed from dielectric constrictions for DNA or protein focusing by dielectrophoresis, multi-layer nanoburger and nanoburger multiplets for optimized surface-plasma enhanced Raman scattering for protein detection, and biomolecular motor-based nanosystems. The development of advanced nanopatterning techniques promises reliable and high-throughput manufacturing of nanodevices which could impact significantly on the areas of genomics, proteomics, drug discovery and molecular clinical diagnostics.
AB - We report our fabrication of nanoscale devices using electron beam and nanoimprint lithography (NIL). We focus our study in the emerging fields of NIL, nanophotonics and nanobiotechnology and give a few examples as to how these nanodevices may be applied toward genomic and proteomic applications for molecular analysis. The examples include reverse NIL-fabricated nanofluidic channels for DNA stretching, nanoscale molecular traps constructed from dielectric constrictions for DNA or protein focusing by dielectrophoresis, multi-layer nanoburger and nanoburger multiplets for optimized surface-plasma enhanced Raman scattering for protein detection, and biomolecular motor-based nanosystems. The development of advanced nanopatterning techniques promises reliable and high-throughput manufacturing of nanodevices which could impact significantly on the areas of genomics, proteomics, drug discovery and molecular clinical diagnostics.
KW - Biomotors
KW - Biosensors
KW - Dielectrophoresis
KW - Genomics
KW - Nanofabrication
KW - Nanofluidics
KW - Nanoimprint lithography
KW - Nanophotonics
KW - Proteomics
KW - SERS
UR - http://www.scopus.com/inward/record.url?scp=16644395635&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16644395635&partnerID=8YFLogxK
U2 - 10.1117/12.574872
DO - 10.1117/12.574872
M3 - Conference contribution
AN - SCOPUS:16644395635
VL - 5592
SP - 183
EP - 192
BT - Proceedings of SPIE - The International Society for Optical Engineering
A2 - Lai, W.Y.-C.
A2 - Pau, S.
A2 - Lopez, O.D.
ER -