Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications

Chia Fu Chou, Jian Gu, Qihuo Wei, Yingjie Liu, Ravi Gupta, Takeyoshi Nishio, Frederic Zenhausern

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

We report our fabrication of nanoscale devices using electron beam and nanoimprint lithography (NIL). We focus our study in the emerging fields of NIL, nanophotonics and nanobiotechnology and give a few examples as to how these nanodevices may be applied toward genomic and proteomic applications for molecular analysis. The examples include reverse NIL-fabricated nanofluidic channels for DNA stretching, nanoscale molecular traps constructed from dielectric constrictions for DNA or protein focusing by dielectrophoresis, multi-layer nanoburger and nanoburger multiplets for optimized surface-plasma enhanced Raman scattering for protein detection, and biomolecular motor-based nanosystems. The development of advanced nanopatterning techniques promises reliable and high-throughput manufacturing of nanodevices which could impact significantly on the areas of genomics, proteomics, drug discovery and molecular clinical diagnostics.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsW.Y.-C. Lai, S. Pau, O.D. Lopez
Pages183-192
Number of pages10
Volume5592
DOIs
StatePublished - 2005
EventNanofabrication: Technologies, Devices, and Applications - Philadelphia, PA, United States
Duration: Oct 25 2004Oct 28 2004

Other

OtherNanofabrication: Technologies, Devices, and Applications
CountryUnited States
CityPhiladelphia, PA
Period10/25/0410/28/04

Fingerprint

Nanoimprint lithography
lithography
DNA
deoxyribonucleic acid
Nanobiotechnology
Nanofluidics
Nanosystems
proteins
Proteins
Nanophotonics
Electron beam lithography
Electrophoresis
Stretching
Raman scattering
emerging
constrictions
drugs
manufacturing
fine structure
Throughput

Keywords

  • Biomotors
  • Biosensors
  • Dielectrophoresis
  • Genomics
  • Nanofabrication
  • Nanofluidics
  • Nanoimprint lithography
  • Nanophotonics
  • Proteomics
  • SERS

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Chou, C. F., Gu, J., Wei, Q., Liu, Y., Gupta, R., Nishio, T., & Zenhausern, F. (2005). Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications. In WY-C. Lai, S. Pau, & O. D. Lopez (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5592, pp. 183-192). [35] https://doi.org/10.1117/12.574872

Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications. / Chou, Chia Fu; Gu, Jian; Wei, Qihuo; Liu, Yingjie; Gupta, Ravi; Nishio, Takeyoshi; Zenhausern, Frederic.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / W.Y.-C. Lai; S. Pau; O.D. Lopez. Vol. 5592 2005. p. 183-192 35.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chou, CF, Gu, J, Wei, Q, Liu, Y, Gupta, R, Nishio, T & Zenhausern, F 2005, Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications. in WY-C Lai, S Pau & OD Lopez (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5592, 35, pp. 183-192, Nanofabrication: Technologies, Devices, and Applications, Philadelphia, PA, United States, 10/25/04. https://doi.org/10.1117/12.574872
Chou CF, Gu J, Wei Q, Liu Y, Gupta R, Nishio T et al. Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications. In Lai WY-C, Pau S, Lopez OD, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5592. 2005. p. 183-192. 35 https://doi.org/10.1117/12.574872
Chou, Chia Fu ; Gu, Jian ; Wei, Qihuo ; Liu, Yingjie ; Gupta, Ravi ; Nishio, Takeyoshi ; Zenhausern, Frederic. / Nanopatterned structures for biomolecular analysis towards genomic and proteomic applications. Proceedings of SPIE - The International Society for Optical Engineering. editor / W.Y.-C. Lai ; S. Pau ; O.D. Lopez. Vol. 5592 2005. pp. 183-192
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