Nanopharmaceuticals I: Nanocarrier systems in drug delivery

Yun Seok Rhee, Heidi M. Mansour

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

To achieve maximum pharmacological effects with minimum side effects of drugs, drugs should be delivered to target sites without significant distribution to non-target areas. Using pharmaceutical nanocarrier systems for drug delivery is a useful delivery platform for improving target specificity, therapeutic activity, and reducing toxicity of drugs. Various sophisticated nanocarrier systems have been developed for drug delivery, and this review focuses on liposomes, polymeric nanoparticles, polymeric micelles, lipid nanoparticles, microemulsions, nanogels, and submicron lipid emulsions. This review outlines and explores nanocarrier systems for drug delivery by various administration routes including parenteral, oral, transdermal, pulmonary, ocular, and mucosal and discusses the product development and related issues in nanopharmaceutical drug delivery.

Original languageEnglish (US)
Pages (from-to)84-114
Number of pages31
JournalInternational Journal of Nanotechnology
Volume8
Issue number1-2
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Lipid nanoparticles
  • Liposomes
  • Microemulsions
  • Nanogels
  • Polymeric micelles
  • Polymeric nanoparticles
  • Submicron lipid emulsions

ASJC Scopus subject areas

  • Bioengineering
  • Condensed Matter Physics
  • Electrical and Electronic Engineering
  • Materials Chemistry

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