Nanoshells as contrast agents for scatter-based optical imaging

Min Ho Lee, Vengadesan Nammalvar, Andre Gobin, Jennifer Barton, Jennifer West, Rebekah Drezek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Optical properties of gold nanoshell-based contrast agents for optical coherence tomography (OCT) were determined using calculations based on concentric sphere Mie scattering theory. Nanoshells capable of optimal optical scattering in the near infrared (NIR) were subsequently fabricated. We show that scattering nanoshell possess higher backscattering efficiencies at longer wavelengths. Results show enhanced OCT signal intensities after addition of gold nanoshells to scattering tissue phantoms. In addition, in vivo mouse tumor model studies show clear evidence of enhancement of tumor scatter after nanoshell injection as compared to control (Phosphate Buffered Saline, PBS) injections, further demonstrating the potential of gold nanoshells as NIR contrast agents to improve scattering-based optical imaging technologies. In addition to the data shown in this preliminary paper, the talk will present more recent data using immunotargeted nanoshells for molecular contrast OCT.

Original languageEnglish (US)
Title of host publication2006 3rd IEEE International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro - Proceedings
Pages371-374
Number of pages4
StatePublished - Nov 17 2006
Event2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Arlington, VA, United States
Duration: Apr 6 2006Apr 9 2006

Publication series

Name2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings
Volume2006

Other

Other2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro
CountryUnited States
CityArlington, VA
Period4/6/064/9/06

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Lee, M. H., Nammalvar, V., Gobin, A., Barton, J., West, J., & Drezek, R. (2006). Nanoshells as contrast agents for scatter-based optical imaging. In 2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings (pp. 371-374). [1624930] (2006 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro - Proceedings; Vol. 2006).