Nanoshells for integrated diagnosis and therapy of cancer

Alex W H Lin, Christopher H. Loo, Leon R. Hirsch, Jennifer K Barton, Min Ho Lee, Naomi J. Halas, Jennifer L. West, Rebekah A. Drezek

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

Metal nanoshells are a novel type of composite nanoparticle consisting of a dielectric core covered by a thin metallic shell which is typically gold. Nanoshells possess highly favorable optical and chemical properties for biomedical imaging and therapeutic applications. By varying the relative the dimensions of the core and the shell, the optical resonance of these nanoparticles can be precisely and systematically varied over a broad wavelength region ranging from the near-UV to the mid-infrared. This range includes the near-infrared (NIR) region where tissue transmissivity peaks. In addition, nanoshells offer other advantages over conventional organic dye imaging agents, including improved optical properties and reduced susceptibility to chemical/thermal denaturation. Furthermore, the same conjugation protocols used to bind biomolecules to gold colloid are easily modified for nanoshells. We first review the synthesis of gold nanoshells and illustrate how the core/shell ratio and overall size of a nanoshell influences its scattering and absorption properties. We then describe several examples of nanoshell-based diagnostic and therapeutic approaches including the development of nanoshell bioconjugates for molecular imaging, the use of scattering nanoshells as contrast agents for optical coherence tomography (OCT), and the use of absorbing nanoshells in NIR thermal therapy of tumors.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsM.S. Islam, A.K. Dutta
Pages308-316
Number of pages9
Volume5593
DOIs
StatePublished - 2004
EventNanosensing Materials and Devices - Philadelphia, PA, United States
Duration: Oct 25 2004Oct 28 2004

Other

OtherNanosensing Materials and Devices
CountryUnited States
CityPhiladelphia, PA
Period10/25/0410/28/04

Fingerprint

Nanoshells
therapy
cancer
gold
optical properties
nanoparticles
optical resonance
transmissivity
biopolymer denaturation
conjugation
scattering
chemical properties
colloids
tumors
tomography
dyes
Gold
magnetic permeability
Infrared radiation
composite materials

Keywords

  • Cancer
  • Contrast agents
  • Molecular imaging
  • Nanoparticles
  • Nanoshells
  • Nanotechnology
  • Optical Coherence Tomography
  • Photothermal therapy

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Lin, A. W. H., Loo, C. H., Hirsch, L. R., Barton, J. K., Lee, M. H., Halas, N. J., ... Drezek, R. A. (2004). Nanoshells for integrated diagnosis and therapy of cancer. In M. S. Islam, & A. K. Dutta (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5593, pp. 308-316). [51] https://doi.org/10.1117/12.570267

Nanoshells for integrated diagnosis and therapy of cancer. / Lin, Alex W H; Loo, Christopher H.; Hirsch, Leon R.; Barton, Jennifer K; Lee, Min Ho; Halas, Naomi J.; West, Jennifer L.; Drezek, Rebekah A.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / M.S. Islam; A.K. Dutta. Vol. 5593 2004. p. 308-316 51.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lin, AWH, Loo, CH, Hirsch, LR, Barton, JK, Lee, MH, Halas, NJ, West, JL & Drezek, RA 2004, Nanoshells for integrated diagnosis and therapy of cancer. in MS Islam & AK Dutta (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5593, 51, pp. 308-316, Nanosensing Materials and Devices, Philadelphia, PA, United States, 10/25/04. https://doi.org/10.1117/12.570267
Lin AWH, Loo CH, Hirsch LR, Barton JK, Lee MH, Halas NJ et al. Nanoshells for integrated diagnosis and therapy of cancer. In Islam MS, Dutta AK, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5593. 2004. p. 308-316. 51 https://doi.org/10.1117/12.570267
Lin, Alex W H ; Loo, Christopher H. ; Hirsch, Leon R. ; Barton, Jennifer K ; Lee, Min Ho ; Halas, Naomi J. ; West, Jennifer L. ; Drezek, Rebekah A. / Nanoshells for integrated diagnosis and therapy of cancer. Proceedings of SPIE - The International Society for Optical Engineering. editor / M.S. Islam ; A.K. Dutta. Vol. 5593 2004. pp. 308-316
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