Natural dissolved organic matter affects electrospray ionization during analysis of emerging contaminants by mass spectrometry

Samanthi Wickramasekara, Selene Hernández-Ruiz, Leif M Abrell, Robert G Arnold, Jon Chorover

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dissolved organic matter (DOM), present in many forms in water, can interfere with analysis of organic contaminants by atmospheric pressure ionization-mass spectrometry. A quantitative analysis of this interference, or matrix effect, on organic contaminant target analyte measurements was carried out using un-fractionated and fractionated dissolved natural organic matter from the Suwannee River, GA (SROM), a standard reference material, that was directly infused into the tandem mass spectrometer during multiple reaction monitoring (MRM) of a suite of endocrine disrupting compounds-pharmaceuticals and personal care products (EDC/PPCPs). Most target analytes suffered signal suppression in the presence of both fractionated and un-fractionated SROM, however greater interferences were measured with fractionated relative to bulk SROM. This finding is consistent with the view of organic matter as a supramolecular association of low molecular mass components having separate charged and structural features revealed only after dissociation.

Original languageEnglish (US)
Pages (from-to)77-84
Number of pages8
JournalAnalytica Chimica Acta
Volume717
DOIs
StatePublished - Mar 2 2012

Fingerprint

Electrospray ionization
Pharmaceutical Services
Atmospheric Pressure
Rivers
dissolved organic matter
Biological materials
Mass spectrometry
Mass Spectrometry
ionization
mass spectrometry
Impurities
organic matter
pollutant
Water
quantitative analysis
atmospheric pressure
spectrometer
Molecular mass
Mass spectrometers
Atmospheric pressure

Keywords

  • Dissolved organic matter
  • Electrospray ionization
  • Endocrine disrupting chemicals (EDCs)
  • Matrix effect
  • Pharmaceuticals and personal care products (PPCPs)
  • Ultra high pressure liquid chromatography-tandem mass spectrometry (UHPLC-MSMS)

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Cite this

Natural dissolved organic matter affects electrospray ionization during analysis of emerging contaminants by mass spectrometry. / Wickramasekara, Samanthi; Hernández-Ruiz, Selene; Abrell, Leif M; Arnold, Robert G; Chorover, Jon.

In: Analytica Chimica Acta, Vol. 717, 02.03.2012, p. 77-84.

Research output: Contribution to journalArticle

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