Natural history of portal hypertension.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A rise in pressure in the portal vein is a frequent occurrence in patients with cirrhosis. One common manifestation affecting at least 50% of cirrhosis patients is the development of gastroesophageal varices and portal hypertensive gastropathy. Bleeding from gastric or esophageal varices will occur in approximately 1/4 of cirrhotic patients with an associated high mortality. Large esophageal varices that have red color signs and isolated gastric varices in the fundus of the stomach are most likely to hemorrhage. The greatest risk of bleeding is during the first year following the index endoscopy. Once varices have bled they are almost certain to rebleed in the absence of therapy. Similarly, severe portal hypertensive gastropathy is likely to cause chronic blood loss. Knowledge of the natural history of gastroesophageal varices allows for the development of effective treatment strategies.

Original languageEnglish (US)
JournalClinics in Liver Disease
Volume1
Issue number1
StatePublished - May 1997
Externally publishedYes

Fingerprint

Esophageal and Gastric Varices
Varicose Veins
Portal Hypertension
Hemorrhage
Fibrosis
Portal Vein
Endoscopy
Stomach
Color
Pressure
Mortality
Therapeutics

ASJC Scopus subject areas

  • Hepatology

Cite this

Natural history of portal hypertension. / Boyer, Thomas D.

In: Clinics in Liver Disease, Vol. 1, No. 1, 05.1997.

Research output: Contribution to journalArticle

@article{95286fe489d3424cab7bc7da788cc7a5,
title = "Natural history of portal hypertension.",
abstract = "A rise in pressure in the portal vein is a frequent occurrence in patients with cirrhosis. One common manifestation affecting at least 50{\%} of cirrhosis patients is the development of gastroesophageal varices and portal hypertensive gastropathy. Bleeding from gastric or esophageal varices will occur in approximately 1/4 of cirrhotic patients with an associated high mortality. Large esophageal varices that have red color signs and isolated gastric varices in the fundus of the stomach are most likely to hemorrhage. The greatest risk of bleeding is during the first year following the index endoscopy. Once varices have bled they are almost certain to rebleed in the absence of therapy. Similarly, severe portal hypertensive gastropathy is likely to cause chronic blood loss. Knowledge of the natural history of gastroesophageal varices allows for the development of effective treatment strategies.",
author = "Boyer, {Thomas D}",
year = "1997",
month = "5",
language = "English (US)",
volume = "1",
journal = "Clinics in Liver Disease",
issn = "1089-3261",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Natural history of portal hypertension.

AU - Boyer, Thomas D

PY - 1997/5

Y1 - 1997/5

N2 - A rise in pressure in the portal vein is a frequent occurrence in patients with cirrhosis. One common manifestation affecting at least 50% of cirrhosis patients is the development of gastroesophageal varices and portal hypertensive gastropathy. Bleeding from gastric or esophageal varices will occur in approximately 1/4 of cirrhotic patients with an associated high mortality. Large esophageal varices that have red color signs and isolated gastric varices in the fundus of the stomach are most likely to hemorrhage. The greatest risk of bleeding is during the first year following the index endoscopy. Once varices have bled they are almost certain to rebleed in the absence of therapy. Similarly, severe portal hypertensive gastropathy is likely to cause chronic blood loss. Knowledge of the natural history of gastroesophageal varices allows for the development of effective treatment strategies.

AB - A rise in pressure in the portal vein is a frequent occurrence in patients with cirrhosis. One common manifestation affecting at least 50% of cirrhosis patients is the development of gastroesophageal varices and portal hypertensive gastropathy. Bleeding from gastric or esophageal varices will occur in approximately 1/4 of cirrhotic patients with an associated high mortality. Large esophageal varices that have red color signs and isolated gastric varices in the fundus of the stomach are most likely to hemorrhage. The greatest risk of bleeding is during the first year following the index endoscopy. Once varices have bled they are almost certain to rebleed in the absence of therapy. Similarly, severe portal hypertensive gastropathy is likely to cause chronic blood loss. Knowledge of the natural history of gastroesophageal varices allows for the development of effective treatment strategies.

UR - http://www.scopus.com/inward/record.url?scp=0002281669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0002281669&partnerID=8YFLogxK

M3 - Article

C2 - 15562666

AN - SCOPUS:0002281669

VL - 1

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

SN - 1089-3261

IS - 1

ER -