Natural products from plant-associated microorganisms: Distribution, structural diversity, bioactivity, and implications of their occurrence

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573 Scopus citations


A growing body of evidence suggests that plant-associated microorganisms, especially endophytic and rhizosphere bacteria and fungi, represent a huge and largely untapped resource of natural products with chemical structures that have been optimized by evolution for biological and ecological relevance. A diverse array of bioactive small molecule natural products has been encountered in these microorganisms. The structures of over 230 metabolites isolated and characterized from over 70 plant-associated microbial strains during the past four years are presented with information on their hosts, culture conditions, and biological activities. Some significant biological and ecological implications of their occurrence are also reviewed.

Original languageEnglish (US)
Pages (from-to)509-526
Number of pages18
JournalJournal of Natural Products
Issue number3
Publication statusPublished - Mar 2006


ASJC Scopus subject areas

  • Plant Science
  • Chemistry (miscellaneous)
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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