NCAM (CD56)-positive malignant lymphoma

W. F. Kern, Catherine S Perry, Thomas P Miller, T. M. Grogan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

CD56 has been found to identify an isoform of the neural cell adhesion (NCAM). NCAM is a member of the immunoglobulin superfamily of cell adhesion molecules; it is related to a variety of leukocyte antigens and to several cell adhesion molecules believed relevant to malignant behavior in a variety of neoplasms. It contains poly sialic acid, which appears to regulate binding avidity of NCAM and other cell adhesion processes. We have identified a group of NCAM-positive lymphomas. Compared to a group of NCAM-negative lymphomas, this group exhibited frequent involvement of unusual sites and a generally aggressive course. Another series of CD56-positive hematolymphoid malignancies has recently been described, from Hong Kong; this group also exhibited involvement of unusual sites and displayed a very aggressive course. Together these series suggest that NCAM on lymphoma is of biological and clinical significance in terms of tumor behavior and spread.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalLeukemia and Lymphoma
Volume12
Issue number1-2
DOIs
StatePublished - 1993

Fingerprint

Neural Cell Adhesion Molecules
Lymphoma
Cell Adhesion Molecules
Cell Adhesion
Neoplasms
Hong Kong
N-Acetylneuraminic Acid
HLA Antigens
Immunoglobulins
Protein Isoforms

Keywords

  • CD56
  • Cell adhesion molecules
  • Localization
  • Malignant lymphoma
  • Neural cell adhesion molecule
  • Polysialic acid

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

NCAM (CD56)-positive malignant lymphoma. / Kern, W. F.; Perry, Catherine S; Miller, Thomas P; Grogan, T. M.

In: Leukemia and Lymphoma, Vol. 12, No. 1-2, 1993, p. 1-10.

Research output: Contribution to journalArticle

Kern, W. F. ; Perry, Catherine S ; Miller, Thomas P ; Grogan, T. M. / NCAM (CD56)-positive malignant lymphoma. In: Leukemia and Lymphoma. 1993 ; Vol. 12, No. 1-2. pp. 1-10.
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