Nebulin, a multi-functional giant

Miensheng Chu, Carol Gregorio, Christopher T. Pappas

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Efficient muscle contraction in skeletal muscle is predicated on the regulation ofactin filament lengths.Inone long-standing model that was prominent for decades, the giant protein nebulin was proposed to functionas a 'molecular ruler' tospecify the lengths ofthe thin filaments. This theory was questioned by many observations, including experiments in which the length of nebulin was manipulated in skeletal myocytes; this approach revealed that nebulin functions to stabilize filamentous actin, allowing thin filaments to reach mature lengths. In addition, more recent data, mostly from in vivo models and identification of new interacting partners, have provided evidence that nebulin is not merely a structural protein. Nebulin plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly.

Original languageEnglish (US)
Pages (from-to)146-152
Number of pages7
JournalJournal of Experimental Biology
Volume219
Issue number2
DOIs
StatePublished - Jan 1 2016

Fingerprint

muscle
contraction
muscle contraction
Muscle Contraction
protein
myofibrils
structural proteins
Myofibrils
actin
Skeletal Muscle Fibers
skeletal muscle
Actins
Skeletal Muscle
Proteins
nebulin
experiment
proteins
regulation

Keywords

  • Actin filament
  • Sarcomere
  • Skeletal muscle

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Physiology
  • Insect Science
  • Aquatic Science

Cite this

Nebulin, a multi-functional giant. / Chu, Miensheng; Gregorio, Carol; Pappas, Christopher T.

In: Journal of Experimental Biology, Vol. 219, No. 2, 01.01.2016, p. 146-152.

Research output: Contribution to journalArticle

Chu, Miensheng ; Gregorio, Carol ; Pappas, Christopher T. / Nebulin, a multi-functional giant. In: Journal of Experimental Biology. 2016 ; Vol. 219, No. 2. pp. 146-152.
@article{53737e5e9de94968bbc939d3281bdebd,
title = "Nebulin, a multi-functional giant",
abstract = "Efficient muscle contraction in skeletal muscle is predicated on the regulation ofactin filament lengths.Inone long-standing model that was prominent for decades, the giant protein nebulin was proposed to functionas a 'molecular ruler' tospecify the lengths ofthe thin filaments. This theory was questioned by many observations, including experiments in which the length of nebulin was manipulated in skeletal myocytes; this approach revealed that nebulin functions to stabilize filamentous actin, allowing thin filaments to reach mature lengths. In addition, more recent data, mostly from in vivo models and identification of new interacting partners, have provided evidence that nebulin is not merely a structural protein. Nebulin plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly.",
keywords = "Actin filament, Sarcomere, Skeletal muscle",
author = "Miensheng Chu and Carol Gregorio and Pappas, {Christopher T.}",
year = "2016",
month = "1",
day = "1",
doi = "10.1242/jeb.126383",
language = "English (US)",
volume = "219",
pages = "146--152",
journal = "Journal of Experimental Biology",
issn = "0022-0949",
publisher = "Company of Biologists Ltd",
number = "2",

}

TY - JOUR

T1 - Nebulin, a multi-functional giant

AU - Chu, Miensheng

AU - Gregorio, Carol

AU - Pappas, Christopher T.

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Efficient muscle contraction in skeletal muscle is predicated on the regulation ofactin filament lengths.Inone long-standing model that was prominent for decades, the giant protein nebulin was proposed to functionas a 'molecular ruler' tospecify the lengths ofthe thin filaments. This theory was questioned by many observations, including experiments in which the length of nebulin was manipulated in skeletal myocytes; this approach revealed that nebulin functions to stabilize filamentous actin, allowing thin filaments to reach mature lengths. In addition, more recent data, mostly from in vivo models and identification of new interacting partners, have provided evidence that nebulin is not merely a structural protein. Nebulin plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly.

AB - Efficient muscle contraction in skeletal muscle is predicated on the regulation ofactin filament lengths.Inone long-standing model that was prominent for decades, the giant protein nebulin was proposed to functionas a 'molecular ruler' tospecify the lengths ofthe thin filaments. This theory was questioned by many observations, including experiments in which the length of nebulin was manipulated in skeletal myocytes; this approach revealed that nebulin functions to stabilize filamentous actin, allowing thin filaments to reach mature lengths. In addition, more recent data, mostly from in vivo models and identification of new interacting partners, have provided evidence that nebulin is not merely a structural protein. Nebulin plays a role in numerous cellular processes including regulation of muscle contraction, Z-disc formation, and myofibril organization and assembly.

KW - Actin filament

KW - Sarcomere

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=84962544032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84962544032&partnerID=8YFLogxK

U2 - 10.1242/jeb.126383

DO - 10.1242/jeb.126383

M3 - Article

C2 - 26792324

AN - SCOPUS:84962544032

VL - 219

SP - 146

EP - 152

JO - Journal of Experimental Biology

JF - Journal of Experimental Biology

SN - 0022-0949

IS - 2

ER -