Neoadjuvant therapy: A novel and effective treatment for stage IIIb non-small cell lung cancer

Valerie W. Rusch, Kathy S. Albain, John J. Crowley, Thomas W. Rice, Vassyl Lonchyna, Robert McKenna, Keith Stelzer, Robert B Livingston

Research output: Contribution to journalArticle

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Abstract

Neoadjuvant therapy has become an accepted treatment for stage IIIa, but not for stage IIIb, non-small cell lung cancer, which is usually considered incurable and treated nonsurgically. We determined the feasibility of neoadjuvant therapy in the setting of stage IIIb non-small cell lung cancer in a prospective multiinstitutional trial. For patients to be eligible for entry into the study, they had to have pathologically documented T1-4 N2-3 disease. Treatment consisted of: (1) cisplatin (50 mg/m2) given on days 1, 8, 29, and 36 plus VP-16 (50 mg/m2) given on days 1 to 5 and 29 to 33, together with concurrent radiotherapy (4,500 cGy; 180 cGy per daily fraction); and (2) surgical resection performed 3 to 5 weeks after induction of medical therapy, if the response was stable, partial, or complete. Of the 126 total eligible patients entered into the study, 51 patients had stage IIIb rumors (24 with T4 tumors and 27 with N3 disease). This consisted of 34 men and 17 women with a median age of 57 years. Thirty-two (63%) patients (18 with T4 tumors and 14 with N3 disease) underwent resection of the primary tumor, with a 5.2% operative mortality. There was no difference in the operative time, blood loss, and length of hospital stay for the T4 versus the N3 patients. For all 51 patients, survival at 2 years was 39%. Sites of relapse in all patients were mainly distant, even though patients with N3 disease did not initially have involved N3 nodes resected. Our experience shows the feasibility of instituting neoadjuvant therapy in patients with stage IIIb non-small cell lung cancer, and suggests that such patients could be included in future trials designed to evaluate the role of surgical resection in the combined-modality treatment of stage III non-small cell lung cancer.

Original languageEnglish (US)
Pages (from-to)290-295
Number of pages6
JournalAnnals of Thoracic Surgery
Volume58
Issue number2
StatePublished - Aug 1994
Externally publishedYes

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Neoadjuvant Therapy
Non-Small Cell Lung Carcinoma
Therapeutics
Length of Stay
Neoplasms
Etoposide
Operative Time
Cisplatin
Radiotherapy
Recurrence

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Rusch, V. W., Albain, K. S., Crowley, J. J., Rice, T. W., Lonchyna, V., McKenna, R., ... Livingston, R. B. (1994). Neoadjuvant therapy: A novel and effective treatment for stage IIIb non-small cell lung cancer. Annals of Thoracic Surgery, 58(2), 290-295.

Neoadjuvant therapy : A novel and effective treatment for stage IIIb non-small cell lung cancer. / Rusch, Valerie W.; Albain, Kathy S.; Crowley, John J.; Rice, Thomas W.; Lonchyna, Vassyl; McKenna, Robert; Stelzer, Keith; Livingston, Robert B.

In: Annals of Thoracic Surgery, Vol. 58, No. 2, 08.1994, p. 290-295.

Research output: Contribution to journalArticle

Rusch, VW, Albain, KS, Crowley, JJ, Rice, TW, Lonchyna, V, McKenna, R, Stelzer, K & Livingston, RB 1994, 'Neoadjuvant therapy: A novel and effective treatment for stage IIIb non-small cell lung cancer', Annals of Thoracic Surgery, vol. 58, no. 2, pp. 290-295.
Rusch VW, Albain KS, Crowley JJ, Rice TW, Lonchyna V, McKenna R et al. Neoadjuvant therapy: A novel and effective treatment for stage IIIb non-small cell lung cancer. Annals of Thoracic Surgery. 1994 Aug;58(2):290-295.
Rusch, Valerie W. ; Albain, Kathy S. ; Crowley, John J. ; Rice, Thomas W. ; Lonchyna, Vassyl ; McKenna, Robert ; Stelzer, Keith ; Livingston, Robert B. / Neoadjuvant therapy : A novel and effective treatment for stage IIIb non-small cell lung cancer. In: Annals of Thoracic Surgery. 1994 ; Vol. 58, No. 2. pp. 290-295.
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abstract = "Neoadjuvant therapy has become an accepted treatment for stage IIIa, but not for stage IIIb, non-small cell lung cancer, which is usually considered incurable and treated nonsurgically. We determined the feasibility of neoadjuvant therapy in the setting of stage IIIb non-small cell lung cancer in a prospective multiinstitutional trial. For patients to be eligible for entry into the study, they had to have pathologically documented T1-4 N2-3 disease. Treatment consisted of: (1) cisplatin (50 mg/m2) given on days 1, 8, 29, and 36 plus VP-16 (50 mg/m2) given on days 1 to 5 and 29 to 33, together with concurrent radiotherapy (4,500 cGy; 180 cGy per daily fraction); and (2) surgical resection performed 3 to 5 weeks after induction of medical therapy, if the response was stable, partial, or complete. Of the 126 total eligible patients entered into the study, 51 patients had stage IIIb rumors (24 with T4 tumors and 27 with N3 disease). This consisted of 34 men and 17 women with a median age of 57 years. Thirty-two (63{\%}) patients (18 with T4 tumors and 14 with N3 disease) underwent resection of the primary tumor, with a 5.2{\%} operative mortality. There was no difference in the operative time, blood loss, and length of hospital stay for the T4 versus the N3 patients. For all 51 patients, survival at 2 years was 39{\%}. Sites of relapse in all patients were mainly distant, even though patients with N3 disease did not initially have involved N3 nodes resected. Our experience shows the feasibility of instituting neoadjuvant therapy in patients with stage IIIb non-small cell lung cancer, and suggests that such patients could be included in future trials designed to evaluate the role of surgical resection in the combined-modality treatment of stage III non-small cell lung cancer.",
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