Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Paul Brotherton, Wolfgang Haak, Jennifer Templeton, Guido Brandt, Julien Soubrier, Christina Jane Adler, Stephen M. Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis Van Oven, Rosalie Kenyon, Mark B. Van Der Hoek, Jonas Korlach, Khai Luong, Simon Y W Ho, Lluis Quintana-Murci, Doron M. Behar, Harald MellerKurt W. Alt, Alan Cooper, Syama Adhikarla, Arun Kumar Ganesh Prasad, Ramasamy Pitchappan, Arun Varatharajan Santhakumari, Elena Balanovska, Oleg Balanovsky, Jaume Bertranpetit, David Comas, Begoña Martínez-Cruz, Marta Melé, Andrew C. Clarke, Elizabeth A. Matisoo-Smith, Matthew C. Dulik, Jill B. Gaieski, Amanda C. Owings, Theodore G. Schurr, Miguel G. Vilar, Angela Hobbs, Himla Soodyall, Asif Javed, Laxmi Parida, Daniel E. Platt, Ajay K. Royyuru, Li Jin, Shilin Li, Matthew E. Kaplan, Nirav C Merchant, R. John Mitchell, Colin Renfrew, Daniela R. Lacerda, Fabrício R. Santos, David F. Soria Hernanz, R. Spencer Wells, Pandikumar Swamikrishnan, Chris Tyler-Smith, Pedro Paulo Vieira, Janet S. Ziegle

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (∼19%) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

Original languageEnglish (US)
Article number1764
JournalNature Communications
Volume4
DOIs
StatePublished - 2013

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Modern 1601-history
Mitochondrial Genome
genome
Mutation Rate
Mitochondrial DNA
Mitochondria
Genes
History
Mothers
histories
Genome
Central Europe
mitochondria
Bronze
bronzes
mutations
bells
Population
high current
deoxyribonucleic acid

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Brotherton, P., Haak, W., Templeton, J., Brandt, G., Soubrier, J., Jane Adler, C., ... Ziegle, J. S. (2013). Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. Nature Communications, 4, [1764]. https://doi.org/10.1038/ncomms2656

Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. / Brotherton, Paul; Haak, Wolfgang; Templeton, Jennifer; Brandt, Guido; Soubrier, Julien; Jane Adler, Christina; Richards, Stephen M.; Sarkissian, Clio Der; Ganslmeier, Robert; Friederich, Susanne; Dresely, Veit; Van Oven, Mannis; Kenyon, Rosalie; Van Der Hoek, Mark B.; Korlach, Jonas; Luong, Khai; Ho, Simon Y W; Quintana-Murci, Lluis; Behar, Doron M.; Meller, Harald; Alt, Kurt W.; Cooper, Alan; Adhikarla, Syama; Ganesh Prasad, Arun Kumar; Pitchappan, Ramasamy; Varatharajan Santhakumari, Arun; Balanovska, Elena; Balanovsky, Oleg; Bertranpetit, Jaume; Comas, David; Martínez-Cruz, Begoña; Melé, Marta; Clarke, Andrew C.; Matisoo-Smith, Elizabeth A.; Dulik, Matthew C.; Gaieski, Jill B.; Owings, Amanda C.; Schurr, Theodore G.; Vilar, Miguel G.; Hobbs, Angela; Soodyall, Himla; Javed, Asif; Parida, Laxmi; Platt, Daniel E.; Royyuru, Ajay K.; Jin, Li; Li, Shilin; Kaplan, Matthew E.; Merchant, Nirav C; John Mitchell, R.; Renfrew, Colin; Lacerda, Daniela R.; Santos, Fabrício R.; Soria Hernanz, David F.; Spencer Wells, R.; Swamikrishnan, Pandikumar; Tyler-Smith, Chris; Paulo Vieira, Pedro; Ziegle, Janet S.

In: Nature Communications, Vol. 4, 1764, 2013.

Research output: Contribution to journalArticle

Brotherton, P, Haak, W, Templeton, J, Brandt, G, Soubrier, J, Jane Adler, C, Richards, SM, Sarkissian, CD, Ganslmeier, R, Friederich, S, Dresely, V, Van Oven, M, Kenyon, R, Van Der Hoek, MB, Korlach, J, Luong, K, Ho, SYW, Quintana-Murci, L, Behar, DM, Meller, H, Alt, KW, Cooper, A, Adhikarla, S, Ganesh Prasad, AK, Pitchappan, R, Varatharajan Santhakumari, A, Balanovska, E, Balanovsky, O, Bertranpetit, J, Comas, D, Martínez-Cruz, B, Melé, M, Clarke, AC, Matisoo-Smith, EA, Dulik, MC, Gaieski, JB, Owings, AC, Schurr, TG, Vilar, MG, Hobbs, A, Soodyall, H, Javed, A, Parida, L, Platt, DE, Royyuru, AK, Jin, L, Li, S, Kaplan, ME, Merchant, NC, John Mitchell, R, Renfrew, C, Lacerda, DR, Santos, FR, Soria Hernanz, DF, Spencer Wells, R, Swamikrishnan, P, Tyler-Smith, C, Paulo Vieira, P & Ziegle, JS 2013, 'Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans', Nature Communications, vol. 4, 1764. https://doi.org/10.1038/ncomms2656
Brotherton P, Haak W, Templeton J, Brandt G, Soubrier J, Jane Adler C et al. Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. Nature Communications. 2013;4. 1764. https://doi.org/10.1038/ncomms2656
Brotherton, Paul ; Haak, Wolfgang ; Templeton, Jennifer ; Brandt, Guido ; Soubrier, Julien ; Jane Adler, Christina ; Richards, Stephen M. ; Sarkissian, Clio Der ; Ganslmeier, Robert ; Friederich, Susanne ; Dresely, Veit ; Van Oven, Mannis ; Kenyon, Rosalie ; Van Der Hoek, Mark B. ; Korlach, Jonas ; Luong, Khai ; Ho, Simon Y W ; Quintana-Murci, Lluis ; Behar, Doron M. ; Meller, Harald ; Alt, Kurt W. ; Cooper, Alan ; Adhikarla, Syama ; Ganesh Prasad, Arun Kumar ; Pitchappan, Ramasamy ; Varatharajan Santhakumari, Arun ; Balanovska, Elena ; Balanovsky, Oleg ; Bertranpetit, Jaume ; Comas, David ; Martínez-Cruz, Begoña ; Melé, Marta ; Clarke, Andrew C. ; Matisoo-Smith, Elizabeth A. ; Dulik, Matthew C. ; Gaieski, Jill B. ; Owings, Amanda C. ; Schurr, Theodore G. ; Vilar, Miguel G. ; Hobbs, Angela ; Soodyall, Himla ; Javed, Asif ; Parida, Laxmi ; Platt, Daniel E. ; Royyuru, Ajay K. ; Jin, Li ; Li, Shilin ; Kaplan, Matthew E. ; Merchant, Nirav C ; John Mitchell, R. ; Renfrew, Colin ; Lacerda, Daniela R. ; Santos, Fabrício R. ; Soria Hernanz, David F. ; Spencer Wells, R. ; Swamikrishnan, Pandikumar ; Tyler-Smith, Chris ; Paulo Vieira, Pedro ; Ziegle, Janet S. / Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans. In: Nature Communications. 2013 ; Vol. 4.
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abstract = "Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40{\%}), yet was less common (∼19{\%}) among Early Neolithic farmers (∼5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this 'real-time' genetic data with cultural changes taking place between the Early Neolithic (∼5450 BC) and Bronze Age (∼2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (∼4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (∼2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45{\%} higher than current estimates for human mitochondria.",
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AU - Haak, Wolfgang

AU - Templeton, Jennifer

AU - Brandt, Guido

AU - Soubrier, Julien

AU - Jane Adler, Christina

AU - Richards, Stephen M.

AU - Sarkissian, Clio Der

AU - Ganslmeier, Robert

AU - Friederich, Susanne

AU - Dresely, Veit

AU - Van Oven, Mannis

AU - Kenyon, Rosalie

AU - Van Der Hoek, Mark B.

AU - Korlach, Jonas

AU - Luong, Khai

AU - Ho, Simon Y W

AU - Quintana-Murci, Lluis

AU - Behar, Doron M.

AU - Meller, Harald

AU - Alt, Kurt W.

AU - Cooper, Alan

AU - Adhikarla, Syama

AU - Ganesh Prasad, Arun Kumar

AU - Pitchappan, Ramasamy

AU - Varatharajan Santhakumari, Arun

AU - Balanovska, Elena

AU - Balanovsky, Oleg

AU - Bertranpetit, Jaume

AU - Comas, David

AU - Martínez-Cruz, Begoña

AU - Melé, Marta

AU - Clarke, Andrew C.

AU - Matisoo-Smith, Elizabeth A.

AU - Dulik, Matthew C.

AU - Gaieski, Jill B.

AU - Owings, Amanda C.

AU - Schurr, Theodore G.

AU - Vilar, Miguel G.

AU - Hobbs, Angela

AU - Soodyall, Himla

AU - Javed, Asif

AU - Parida, Laxmi

AU - Platt, Daniel E.

AU - Royyuru, Ajay K.

AU - Jin, Li

AU - Li, Shilin

AU - Kaplan, Matthew E.

AU - Merchant, Nirav C

AU - John Mitchell, R.

AU - Renfrew, Colin

AU - Lacerda, Daniela R.

AU - Santos, Fabrício R.

AU - Soria Hernanz, David F.

AU - Spencer Wells, R.

AU - Swamikrishnan, Pandikumar

AU - Tyler-Smith, Chris

AU - Paulo Vieira, Pedro

AU - Ziegle, Janet S.

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