Neonatal complex arrhythmias possibly related to a TTN mutation

William N. Evans, Ruben J. Acherman, Ian H. Law, Nicholas H. Von Bergen, Ricardo A Samson, Humberto Restrepo

Research output: Contribution to journalArticle

Abstract

We describe a neonate born with complex arrhythmias that included concurrent atrial and ventricular tachycardias. Genetic testing demonstrated a mutation in the TTN gene, which codes for titin, a large protein found in striated muscle sarcomeres. The complex arrhythmias were successfully treated with amiodarone and flecainide. The patient remains asymptomatic with normal biventricular function. We speculate that the complex arrhythmias and TTN gene mutation may be related.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalJournal of Neonatal-Perinatal Medicine
Volume10
Issue number3
DOIs
StatePublished - 2017
Externally publishedYes

Fingerprint

Cardiac Arrhythmias
Mutation
Connectin
Flecainide
Sarcomeres
Striated Muscle
Amiodarone
Genetic Testing
Ventricular Tachycardia
Genes
Newborn Infant
Proteins

Keywords

  • Complex arrhythmia
  • neonate
  • TTN gene mutation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Evans, W. N., Acherman, R. J., Law, I. H., Von Bergen, N. H., Samson, R. A., & Restrepo, H. (2017). Neonatal complex arrhythmias possibly related to a TTN mutation. Journal of Neonatal-Perinatal Medicine, 10(3), 343-346. https://doi.org/10.3233/NPM-16120

Neonatal complex arrhythmias possibly related to a TTN mutation. / Evans, William N.; Acherman, Ruben J.; Law, Ian H.; Von Bergen, Nicholas H.; Samson, Ricardo A; Restrepo, Humberto.

In: Journal of Neonatal-Perinatal Medicine, Vol. 10, No. 3, 2017, p. 343-346.

Research output: Contribution to journalArticle

Evans, WN, Acherman, RJ, Law, IH, Von Bergen, NH, Samson, RA & Restrepo, H 2017, 'Neonatal complex arrhythmias possibly related to a TTN mutation', Journal of Neonatal-Perinatal Medicine, vol. 10, no. 3, pp. 343-346. https://doi.org/10.3233/NPM-16120
Evans, William N. ; Acherman, Ruben J. ; Law, Ian H. ; Von Bergen, Nicholas H. ; Samson, Ricardo A ; Restrepo, Humberto. / Neonatal complex arrhythmias possibly related to a TTN mutation. In: Journal of Neonatal-Perinatal Medicine. 2017 ; Vol. 10, No. 3. pp. 343-346.
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