Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: Mechanism of action in the context of efficacy and safety

Martin Schmelz, Patrick Mantyh, Anne Marie Malfait, John Farrar, Tony Yaksh, Leslie Tive, Lars Viktrup

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Chronic pain continues to be a significant global burden despite the availability of a variety of nonpharmacologic and pharmacologic treatment options. Thus, there is a need for new analgesics with novel mechanisms of action. In this regard, antibodies directed against nerve growth factor (NGF-Abs) are a new class of agents in development for the treatment of chronic pain conditions such as osteoarthritis and chronic low-back pain. This comprehensive narrative review summarizes evidence supporting pronociceptive functions for NGF that include contributing to peripheral and central sensitization through tropomyosin receptor kinase A activation and stimulation of local neuronal sprouting. The potential role of NGF in osteoarthritis and chronic low-back pain signaling is also examined to provide a mechanistic basis for the observed efficacy of NGF-Abs in clinical trials of these particular pain states. Finally, the safety profile of NGF-Abs in terms of common adverse events, joint safety, and nerve structure/function is discussed.

Original languageEnglish (US)
Pages (from-to)2210-2220
Number of pages11
JournalPain
Volume160
Issue number10
DOIs
StatePublished - Oct 1 2019

Keywords

  • Chronic low-back pain
  • Chronic pain
  • Mechanism of action
  • Nerve growth factor
  • Osteoarthritis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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