Network analysis of single-subject fMRI during a finger opposition task

Jason F. Smith, Kewei Chen, Sterling Johnson, Jeannine Morrone-Strupinsky, Eric M. Reiman, Ann Nelson, James R. Moeller, Gene E. Alexandera

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The analysis of functional magnetic resonance imaging (fMRI) data has typically relied on univariate methods to identify areas of brain activity related to cognitive and behavioral task performance. We investigated the ability of multivariate network analysis using a modified form of principal component analysis, the Scaled Subprofile Model (SSM), applied to single-subject fMRI data to identify patterns of interactions among brain regions over time during an anatomically well-characterized simple motor task. We hypothesized that each subject would exhibit correlated patterns of brain activation in several regions known to participate in the regulation of movement including the contralateral motor cortex and the ipsilateral cerebellum. EPI BOLD images were acquired in six healthy participants as they performed a visually and auditorally paced finger opposition task. SSM analysis was applied to the fMR time series on a single-subject basis. Linear combinations of the major principal components that predicted the expected hemodynamic response to the order of experimental conditions were identified for each participant. These combinations of SSM patterns were highly associated with the expected hemodynamic response, an indicator of local neuronal activity, in each participant (0.84 ≤ R2 ≤ 0.97, all P's < 0.0001). As predicted, the combined pattern in each subject was characterized most prominently by relatively increased activations in contralateral sensorimotor cortex and ipsilateral cerebellum. Additionally, all subjects showed areas of relatively decreased activation in the ipsilateral sensorimotor cortex and contralateral cerebellum. The application of network analysis methods, such as SSM, to singlesubject fMRI data can identify patterns of task-specific, functionally interacting brain areas in individual subjects. This approach may helpidentify individual differences in the task-related functional connectivity, track changes in task-related patterns of activity within or between fMRI sessions, and provide a method to identify individual differences in response to treatment.

Original languageEnglish (US)
Pages (from-to)325-332
Number of pages8
JournalNeuroImage
Volume32
Issue number1
DOIs
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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    Smith, J. F., Chen, K., Johnson, S., Morrone-Strupinsky, J., Reiman, E. M., Nelson, A., Moeller, J. R., & Alexandera, G. E. (2006). Network analysis of single-subject fMRI during a finger opposition task. NeuroImage, 32(1), 325-332. https://doi.org/10.1016/j.neuroimage.2005.12.010