Abstract
The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [18F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK). The results reveal consistent networks activated by these behavior conditions that were similar across age. For the young animals, however, the coactivity patterns were distinct between conditions, whereas older animals tended to engage the same networks in each condition. The combined observations of less differentiated networks between distinct behaviors and alterations in functional connections between targeted regions in aging suggest changes in network dynamics as one source of age-related deficits in spatial cognition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 12217-12227 |
| Number of pages | 11 |
| Journal | Journal of Neuroscience |
| Volume | 36 |
| Issue number | 48 |
| DOIs | |
| State | Published - Nov 30 2016 |
Fingerprint
Keywords
- Aging
- Brain circuits
- Spatial cognition
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Network patterns associated with navigation behaviors are altered in aged nonhuman primates. / Engle, James R.; Machado, Christopher J.; Permenter, Michele R.; Vogt, Julie A.; Maurer, Andrew P.; Bulleri, Alicia M.; Barnes, Carol A.
In: Journal of Neuroscience, Vol. 36, No. 48, 30.11.2016, p. 12217-12227.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Network patterns associated with navigation behaviors are altered in aged nonhuman primates
AU - Engle, James R.
AU - Machado, Christopher J.
AU - Permenter, Michele R.
AU - Vogt, Julie A.
AU - Maurer, Andrew P.
AU - Bulleri, Alicia M.
AU - Barnes, Carol A
PY - 2016/11/30
Y1 - 2016/11/30
N2 - The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [18F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK). The results reveal consistent networks activated by these behavior conditions that were similar across age. For the young animals, however, the coactivity patterns were distinct between conditions, whereas older animals tended to engage the same networks in each condition. The combined observations of less differentiated networks between distinct behaviors and alterations in functional connections between targeted regions in aging suggest changes in network dynamics as one source of age-related deficits in spatial cognition.
AB - The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [18F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK). The results reveal consistent networks activated by these behavior conditions that were similar across age. For the young animals, however, the coactivity patterns were distinct between conditions, whereas older animals tended to engage the same networks in each condition. The combined observations of less differentiated networks between distinct behaviors and alterations in functional connections between targeted regions in aging suggest changes in network dynamics as one source of age-related deficits in spatial cognition.
KW - Aging
KW - Brain circuits
KW - Spatial cognition
UR - http://www.scopus.com/inward/record.url?scp=85006021762&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006021762&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.4116-15.2016
DO - 10.1523/JNEUROSCI.4116-15.2016
M3 - Article
C2 - 27903730
AN - SCOPUS:85006021762
VL - 36
SP - 12217
EP - 12227
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 48
ER -