Network patterns associated with navigation behaviors are altered in aged nonhuman primates

James R. Engle, Christopher J. Machado, Michele R. Permenter, Julie A. Vogt, Andrew P. Maurer, Alicia M. Bulleri, Carol A Barnes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [18F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK). The results reveal consistent networks activated by these behavior conditions that were similar across age. For the young animals, however, the coactivity patterns were distinct between conditions, whereas older animals tended to engage the same networks in each condition. The combined observations of less differentiated networks between distinct behaviors and alterations in functional connections between targeted regions in aging suggest changes in network dynamics as one source of age-related deficits in spatial cognition.

Original languageEnglish (US)
Pages (from-to)12217-12227
Number of pages11
JournalJournal of Neuroscience
Volume36
Issue number48
DOIs
StatePublished - Nov 30 2016

Fingerprint

Locomotion
Primates
Spatial Behavior
Aptitude
Fluorodeoxyglucose F18
Brain
Macaca mulatta
Cognition
Head

Keywords

  • Aging
  • Brain circuits
  • Spatial cognition

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Engle, J. R., Machado, C. J., Permenter, M. R., Vogt, J. A., Maurer, A. P., Bulleri, A. M., & Barnes, C. A. (2016). Network patterns associated with navigation behaviors are altered in aged nonhuman primates. Journal of Neuroscience, 36(48), 12217-12227. https://doi.org/10.1523/JNEUROSCI.4116-15.2016

Network patterns associated with navigation behaviors are altered in aged nonhuman primates. / Engle, James R.; Machado, Christopher J.; Permenter, Michele R.; Vogt, Julie A.; Maurer, Andrew P.; Bulleri, Alicia M.; Barnes, Carol A.

In: Journal of Neuroscience, Vol. 36, No. 48, 30.11.2016, p. 12217-12227.

Research output: Contribution to journalArticle

Engle, JR, Machado, CJ, Permenter, MR, Vogt, JA, Maurer, AP, Bulleri, AM & Barnes, CA 2016, 'Network patterns associated with navigation behaviors are altered in aged nonhuman primates', Journal of Neuroscience, vol. 36, no. 48, pp. 12217-12227. https://doi.org/10.1523/JNEUROSCI.4116-15.2016
Engle JR, Machado CJ, Permenter MR, Vogt JA, Maurer AP, Bulleri AM et al. Network patterns associated with navigation behaviors are altered in aged nonhuman primates. Journal of Neuroscience. 2016 Nov 30;36(48):12217-12227. https://doi.org/10.1523/JNEUROSCI.4116-15.2016
Engle, James R. ; Machado, Christopher J. ; Permenter, Michele R. ; Vogt, Julie A. ; Maurer, Andrew P. ; Bulleri, Alicia M. ; Barnes, Carol A. / Network patterns associated with navigation behaviors are altered in aged nonhuman primates. In: Journal of Neuroscience. 2016 ; Vol. 36, No. 48. pp. 12217-12227.
@article{9a7049e8a80149a8824f9af64fd73ba5,
title = "Network patterns associated with navigation behaviors are altered in aged nonhuman primates",
abstract = "The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [18F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK). The results reveal consistent networks activated by these behavior conditions that were similar across age. For the young animals, however, the coactivity patterns were distinct between conditions, whereas older animals tended to engage the same networks in each condition. The combined observations of less differentiated networks between distinct behaviors and alterations in functional connections between targeted regions in aging suggest changes in network dynamics as one source of age-related deficits in spatial cognition.",
keywords = "Aging, Brain circuits, Spatial cognition",
author = "Engle, {James R.} and Machado, {Christopher J.} and Permenter, {Michele R.} and Vogt, {Julie A.} and Maurer, {Andrew P.} and Bulleri, {Alicia M.} and Barnes, {Carol A}",
year = "2016",
month = "11",
day = "30",
doi = "10.1523/JNEUROSCI.4116-15.2016",
language = "English (US)",
volume = "36",
pages = "12217--12227",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "48",

}

TY - JOUR

T1 - Network patterns associated with navigation behaviors are altered in aged nonhuman primates

AU - Engle, James R.

AU - Machado, Christopher J.

AU - Permenter, Michele R.

AU - Vogt, Julie A.

AU - Maurer, Andrew P.

AU - Bulleri, Alicia M.

AU - Barnes, Carol A

PY - 2016/11/30

Y1 - 2016/11/30

N2 - The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [18F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK). The results reveal consistent networks activated by these behavior conditions that were similar across age. For the young animals, however, the coactivity patterns were distinct between conditions, whereas older animals tended to engage the same networks in each condition. The combined observations of less differentiated networks between distinct behaviors and alterations in functional connections between targeted regions in aging suggest changes in network dynamics as one source of age-related deficits in spatial cognition.

AB - The ability to navigate through space involves complex interactions between multiple brain systems. Although it is clear that spatial navigation is impaired during aging, the networks responsible for these altered behaviors are not well understood. Here, we used a within-subject design and [18F]FDG-microPET to capture whole-brain activation patterns in four distinct spatial behaviors from young and aged rhesus macaques: constrained space (CAGE), head-restrained passive locomotion (CHAIR), constrained locomotion in space (TREADMILL), and unconstrained locomotion (WALK). The results reveal consistent networks activated by these behavior conditions that were similar across age. For the young animals, however, the coactivity patterns were distinct between conditions, whereas older animals tended to engage the same networks in each condition. The combined observations of less differentiated networks between distinct behaviors and alterations in functional connections between targeted regions in aging suggest changes in network dynamics as one source of age-related deficits in spatial cognition.

KW - Aging

KW - Brain circuits

KW - Spatial cognition

UR - http://www.scopus.com/inward/record.url?scp=85006021762&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006021762&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.4116-15.2016

DO - 10.1523/JNEUROSCI.4116-15.2016

M3 - Article

C2 - 27903730

AN - SCOPUS:85006021762

VL - 36

SP - 12217

EP - 12227

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 48

ER -