Neural basis of interpersonal traits in neurodegenerative diseases

Marc Sollberger, Christine M. Stanley, Stephen M Wilson, Anett Gyurak, Victoria Beckman, Matthew Growdon, Jung Jang, Michael W. Weiner, Bruce L. Miller, Katherine P. Rankin

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Several functional and structural imaging studies have investigated the neural basis of personality in healthy adults, but human lesions studies are scarce. Personality changes are a common symptom in patients with neurodegenerative diseases like frontotemporal dementia (FTD) and semantic dementia (SD), allowing a unique window into the neural basis of personality. In this study, we used the Interpersonal Adjective Scales to investigate the structural basis of eight interpersonal traits (dominance, arrogance, coldness, introversion, submissiveness, ingenuousness, warmth, and extraversion) in 257 subjects: 214 patients with neurodegenerative diseases such as FTD, SD, progressive nonfluent aphasia, Alzheimer's disease, amnestic mild cognitive impairment, corticobasal degeneration, and progressive supranuclear palsy and 43 healthy elderly people. Measures of interpersonal traits were correlated with regional atrophy pattern using voxel-based morphometry (VBM) analysis of structural MR images. Interpersonal traits mapped onto distinct brain regions depending on the degree to which they involved agency and affiliation. Interpersonal traits high in agency related to left dorsolateral prefrontal and left lateral frontopolar regions, whereas interpersonal traits high in affiliation related to right ventromedial prefrontal and right anteromedial temporal regions. Consistent with the existing literature on neural networks underlying social cognition, these results indicate that brain regions related to externally focused, executive control-related processes underlie agentic interpersonal traits such as dominance, whereas brain regions related to internally focused, emotion- and reward-related processes underlie affiliative interpersonal traits such as warmth. In addition, these findings indicate that interpersonal traits are subserved by complex neural networks rather than discrete anatomic areas.

Original languageEnglish (US)
Pages (from-to)2812-2827
Number of pages16
JournalNeuropsychologia
Volume47
Issue number13
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Frontotemporal Dementia
Neurodegenerative Diseases
Personality
Brain
Primary Progressive Nonfluent Aphasia
Progressive Supranuclear Palsy
Executive Function
Temporal Lobe
Reward
Social Support
Cognition
Atrophy
Alzheimer Disease
Emotions

Keywords

  • Affiliation
  • Agency
  • Neurodegenerative disease
  • Personality
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Sollberger, M., Stanley, C. M., Wilson, S. M., Gyurak, A., Beckman, V., Growdon, M., ... Rankin, K. P. (2009). Neural basis of interpersonal traits in neurodegenerative diseases. Neuropsychologia, 47(13), 2812-2827. https://doi.org/10.1016/j.neuropsychologia.2009.06.006

Neural basis of interpersonal traits in neurodegenerative diseases. / Sollberger, Marc; Stanley, Christine M.; Wilson, Stephen M; Gyurak, Anett; Beckman, Victoria; Growdon, Matthew; Jang, Jung; Weiner, Michael W.; Miller, Bruce L.; Rankin, Katherine P.

In: Neuropsychologia, Vol. 47, No. 13, 11.2009, p. 2812-2827.

Research output: Contribution to journalArticle

Sollberger, M, Stanley, CM, Wilson, SM, Gyurak, A, Beckman, V, Growdon, M, Jang, J, Weiner, MW, Miller, BL & Rankin, KP 2009, 'Neural basis of interpersonal traits in neurodegenerative diseases', Neuropsychologia, vol. 47, no. 13, pp. 2812-2827. https://doi.org/10.1016/j.neuropsychologia.2009.06.006
Sollberger, Marc ; Stanley, Christine M. ; Wilson, Stephen M ; Gyurak, Anett ; Beckman, Victoria ; Growdon, Matthew ; Jang, Jung ; Weiner, Michael W. ; Miller, Bruce L. ; Rankin, Katherine P. / Neural basis of interpersonal traits in neurodegenerative diseases. In: Neuropsychologia. 2009 ; Vol. 47, No. 13. pp. 2812-2827.
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