Neural correlates of successful and unsuccessful verbal memory encoding

Daniel J. Casasanto, William D.S. Killgore, Joseph A. Maldjian, Guila Glosser, David C. Alsop, Ayanna M. Cooke, Murray Grossman, John A. Detre

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Recent neuroimaging studies suggest that episodic memory encoding involves a network of neocortical structures which may act interdependently with medial temporal lobe (mTL) structures to promote the formation of durable memories, and that activation in certain structures is modulated according to task performance. Functional magnetic resonance imaging (fMRI) was used to determine the neural structures recruited during a verbal episodic encoding task and to examine the relationship between activation during encoding and subsequent recognition memory performance across subjects. Our results show performance-correlated activation during encoding both in neocortical and medial temporal structures. Neocortical activations associated with later successful and unsuccessful recognition memory were found to differ not only in magnitude, but also in hemispheric laterality. These performance-related hemispheric effects, which have not been previously reported, may correspond to between-subject differences in encoding strategy.

Original languageEnglish (US)
Pages (from-to)287-295
Number of pages9
JournalBrain and Language
Volume80
Issue number3
DOIs
StatePublished - 2002

Keywords

  • Encoding
  • Episodic memory
  • Functional imaging
  • Hemispheric effects

ASJC Scopus subject areas

  • Language and Linguistics
  • Experimental and Cognitive Psychology
  • Linguistics and Language
  • Cognitive Neuroscience
  • Speech and Hearing

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