Neural drive to respiratory muscles in the spontaneously breathing rat pup

Ian J. Kidder, Jordan A. Mudery, Elizabeth F Bailey

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The neonatal rodent serves as useful and appropriate model within which to study respiratory system development. Despite an extensive literature that documents respiratory control in vitro, in vivo studies have relied upon whole body plethysmography to determine measures of respiratory frequency and tidal volume. However, plethysmography restricts access to the animal and thus, respiratory muscle electromyographic (EMG) activities have not been recorded in these studies previously. Electromyography yields accurate information about neural respiratory center output to the musculature and therefore, about the control of breathing in the intact animal. In this case, we documented neural drive to respiratory pump and upper airway muscles, electrocardiogram (ECG) and chest wall motions in rat pups up to 10 days of age noting sighs, spontaneous central apneas and hypopneas in room air and with successive increments in fractional inspired CO2 (FICO2). Our findings underscore the advantages of EMG recordings for purposes of determining the magnitude and distribution of neural drive to respiratory muscles and for characterizing the full range of breathing behaviors exhibited by rats in the early postnatal period.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume202
DOIs
StatePublished - Oct 1 2014

Fingerprint

Respiratory Muscles
Respiration
Whole Body Plethysmography
Respiratory Center
Central Sleep Apnea
Plethysmography
Tidal Volume
Thoracic Wall
Electromyography
Respiratory System
Rodentia
Electrocardiography
Air
Muscles
Drive
In Vitro Techniques

Keywords

  • Electromyography
  • Neonate
  • Respiration

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)
  • Medicine(all)

Cite this

Neural drive to respiratory muscles in the spontaneously breathing rat pup. / Kidder, Ian J.; Mudery, Jordan A.; Bailey, Elizabeth F.

In: Respiratory Physiology and Neurobiology, Vol. 202, 01.10.2014, p. 64-70.

Research output: Contribution to journalArticle

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