Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease

Nela Nemcova Elfmarkova, Martin Gajdos, Irena Rektorova, Radek Marecek, Steven Z Rapcsak

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction We used a functional MRI paradigm involving conventional vs. unconventional views of objects to assess bottom-up vs. top-down visual processing in Parkinson's disease (PD) with normal cognition, PD with mild cognitive impairment (MCI), and MCI due to Alzheimer's disease (AD) as compared to healthy controls. We particularly aimed at determining whether the task discriminated between PD with and without MCI and between two MCI groups due to distinct pathologies (AD and PD). Methods 116 right-handed subjects (21 MCI due to AD; 16 PD with normal cognition; 24 PD with MCI; 55 healthy controls) performed a visual object-matching task in a T MR scanner. T statistic maps were computed to contrast task-based activation during unconventional vs. conventional view conditions. One-way ANOVAs and post hoc tests were performed to assess differences across and between groups. Results Both MCI groups performed worse than controls in the unconventional views condition and showed reduced activation of right anterior cingulate cortex and right superior parietal lobule (PD with MCI), and right middle and inferior frontal gyri (MCI due to AD). Neural responses in cortical areas within the ventral and dorsal visual pathway appeared to be preserved in both MCI groups. Receiver operating characteristic analysis of MRI contrast in the right superior parietal lobule distinguished PD with and without MCI with 87.50% sensitivity and 86.98% specificity. Conclusions Impaired recognition of objects presented in unconventional orientations in MCI due to PD and AD was associated with decreased activation of frontoparietal regions, consistent with defective top-down regulation of visual processing. Aberrant activation of superior parietal cortex may serve as an early imaging biomarker of impending cognitive impairment in PD.

Original languageEnglish (US)
Pages (from-to)236-244
Number of pages9
JournalNeuropsychologia
Volume106
DOIs
StatePublished - Nov 1 2017

Fingerprint

Parkinson Disease
Alzheimer Disease
Parietal Lobe
Cognitive Dysfunction
Cognition
Visual Pathways
Gyrus Cinguli
Prefrontal Cortex
ROC Curve
Analysis of Variance
Down-Regulation
Biomarkers
Magnetic Resonance Imaging
Pathology
Sensitivity and Specificity

Keywords

  • Alzheimer's disease
  • fMRI
  • Mild cognitive impairment
  • Parkinson's disease
  • Top-down visual processing

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease. / Nemcova Elfmarkova, Nela; Gajdos, Martin; Rektorova, Irena; Marecek, Radek; Rapcsak, Steven Z.

In: Neuropsychologia, Vol. 106, 01.11.2017, p. 236-244.

Research output: Contribution to journalArticle

Nemcova Elfmarkova, Nela ; Gajdos, Martin ; Rektorova, Irena ; Marecek, Radek ; Rapcsak, Steven Z. / Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease. In: Neuropsychologia. 2017 ; Vol. 106. pp. 236-244.
@article{da49475098f14533988e76f7b5e5336b,
title = "Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease",
abstract = "Introduction We used a functional MRI paradigm involving conventional vs. unconventional views of objects to assess bottom-up vs. top-down visual processing in Parkinson's disease (PD) with normal cognition, PD with mild cognitive impairment (MCI), and MCI due to Alzheimer's disease (AD) as compared to healthy controls. We particularly aimed at determining whether the task discriminated between PD with and without MCI and between two MCI groups due to distinct pathologies (AD and PD). Methods 116 right-handed subjects (21 MCI due to AD; 16 PD with normal cognition; 24 PD with MCI; 55 healthy controls) performed a visual object-matching task in a T MR scanner. T statistic maps were computed to contrast task-based activation during unconventional vs. conventional view conditions. One-way ANOVAs and post hoc tests were performed to assess differences across and between groups. Results Both MCI groups performed worse than controls in the unconventional views condition and showed reduced activation of right anterior cingulate cortex and right superior parietal lobule (PD with MCI), and right middle and inferior frontal gyri (MCI due to AD). Neural responses in cortical areas within the ventral and dorsal visual pathway appeared to be preserved in both MCI groups. Receiver operating characteristic analysis of MRI contrast in the right superior parietal lobule distinguished PD with and without MCI with 87.50{\%} sensitivity and 86.98{\%} specificity. Conclusions Impaired recognition of objects presented in unconventional orientations in MCI due to PD and AD was associated with decreased activation of frontoparietal regions, consistent with defective top-down regulation of visual processing. Aberrant activation of superior parietal cortex may serve as an early imaging biomarker of impending cognitive impairment in PD.",
keywords = "Alzheimer's disease, fMRI, Mild cognitive impairment, Parkinson's disease, Top-down visual processing",
author = "{Nemcova Elfmarkova}, Nela and Martin Gajdos and Irena Rektorova and Radek Marecek and Rapcsak, {Steven Z}",
year = "2017",
month = "11",
day = "1",
doi = "10.1016/j.neuropsychologia.2017.09.034",
language = "English (US)",
volume = "106",
pages = "236--244",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Neural evidence for defective top-down control of visual processing in Parkinson's and Alzheimer's disease

AU - Nemcova Elfmarkova, Nela

AU - Gajdos, Martin

AU - Rektorova, Irena

AU - Marecek, Radek

AU - Rapcsak, Steven Z

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Introduction We used a functional MRI paradigm involving conventional vs. unconventional views of objects to assess bottom-up vs. top-down visual processing in Parkinson's disease (PD) with normal cognition, PD with mild cognitive impairment (MCI), and MCI due to Alzheimer's disease (AD) as compared to healthy controls. We particularly aimed at determining whether the task discriminated between PD with and without MCI and between two MCI groups due to distinct pathologies (AD and PD). Methods 116 right-handed subjects (21 MCI due to AD; 16 PD with normal cognition; 24 PD with MCI; 55 healthy controls) performed a visual object-matching task in a T MR scanner. T statistic maps were computed to contrast task-based activation during unconventional vs. conventional view conditions. One-way ANOVAs and post hoc tests were performed to assess differences across and between groups. Results Both MCI groups performed worse than controls in the unconventional views condition and showed reduced activation of right anterior cingulate cortex and right superior parietal lobule (PD with MCI), and right middle and inferior frontal gyri (MCI due to AD). Neural responses in cortical areas within the ventral and dorsal visual pathway appeared to be preserved in both MCI groups. Receiver operating characteristic analysis of MRI contrast in the right superior parietal lobule distinguished PD with and without MCI with 87.50% sensitivity and 86.98% specificity. Conclusions Impaired recognition of objects presented in unconventional orientations in MCI due to PD and AD was associated with decreased activation of frontoparietal regions, consistent with defective top-down regulation of visual processing. Aberrant activation of superior parietal cortex may serve as an early imaging biomarker of impending cognitive impairment in PD.

AB - Introduction We used a functional MRI paradigm involving conventional vs. unconventional views of objects to assess bottom-up vs. top-down visual processing in Parkinson's disease (PD) with normal cognition, PD with mild cognitive impairment (MCI), and MCI due to Alzheimer's disease (AD) as compared to healthy controls. We particularly aimed at determining whether the task discriminated between PD with and without MCI and between two MCI groups due to distinct pathologies (AD and PD). Methods 116 right-handed subjects (21 MCI due to AD; 16 PD with normal cognition; 24 PD with MCI; 55 healthy controls) performed a visual object-matching task in a T MR scanner. T statistic maps were computed to contrast task-based activation during unconventional vs. conventional view conditions. One-way ANOVAs and post hoc tests were performed to assess differences across and between groups. Results Both MCI groups performed worse than controls in the unconventional views condition and showed reduced activation of right anterior cingulate cortex and right superior parietal lobule (PD with MCI), and right middle and inferior frontal gyri (MCI due to AD). Neural responses in cortical areas within the ventral and dorsal visual pathway appeared to be preserved in both MCI groups. Receiver operating characteristic analysis of MRI contrast in the right superior parietal lobule distinguished PD with and without MCI with 87.50% sensitivity and 86.98% specificity. Conclusions Impaired recognition of objects presented in unconventional orientations in MCI due to PD and AD was associated with decreased activation of frontoparietal regions, consistent with defective top-down regulation of visual processing. Aberrant activation of superior parietal cortex may serve as an early imaging biomarker of impending cognitive impairment in PD.

KW - Alzheimer's disease

KW - fMRI

KW - Mild cognitive impairment

KW - Parkinson's disease

KW - Top-down visual processing

UR - http://www.scopus.com/inward/record.url?scp=85030852584&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030852584&partnerID=8YFLogxK

U2 - 10.1016/j.neuropsychologia.2017.09.034

DO - 10.1016/j.neuropsychologia.2017.09.034

M3 - Article

C2 - 28974380

AN - SCOPUS:85030852584

VL - 106

SP - 236

EP - 244

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

ER -