Neural stem cells improve memory in an inducible mouse model of neuronal loss

Tritia R. Yamasaki, Mathew Blurton-Jones, Debbi A. Morrissette, Masashi Kitazawa, Salvatore Oddo, Frank M. LaFerla

Research output: Contribution to journalArticle

115 Scopus citations

Abstract

Neuronal loss is a major pathological outcome of many common neurological disorders, including ischemia, traumatic brain injury, and Alzheimer disease. Stem cell-based approaches have received considerable attention as a potential means of treatment, although it remains to be determined whether stem cells can ameliorate memory dysfunction, a devastating component of these disorders. We generated a transgenic mouse model in which the tetracycline-off system is used to regulate expression of diphtheria toxin A chain. After induction, we find progressive neuronal loss primarily within the hippocampus, leading to specific impairments in memory. We find that neural stem cells transplanted into the brain after neuronal ablation survive, migrate, differentiate and, most significantly, improve memory. These results show that stem cells may have therapeutic value in diseases and conditions that result in memory loss.

Original languageEnglish (US)
Pages (from-to)11925-11933
Number of pages9
JournalJournal of Neuroscience
Volume27
Issue number44
DOIs
StatePublished - Oct 31 2007

Keywords

  • Ablation
  • Functional recovery
  • Memory
  • Neuronal death
  • Stem cells
  • Transgenic

ASJC Scopus subject areas

  • Neuroscience(all)

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    Yamasaki, T. R., Blurton-Jones, M., Morrissette, D. A., Kitazawa, M., Oddo, S., & LaFerla, F. M. (2007). Neural stem cells improve memory in an inducible mouse model of neuronal loss. Journal of Neuroscience, 27(44), 11925-11933. https://doi.org/10.1523/JNEUROSCI.1627-07.2007