Neural substrates of microstimulation-evoked tingling

A chronaxie study in human somatosensory thalamus

Zelma H T Kiss, Trent R Anderson, Terry Hansen, Dolen Kirstein, Oksana Suchowersky, Bin Hu

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Intra-operative micro-electrode stimulation of sensorimotor thalamus produces paraesthesia or tingling in various body regions and is used to map somatotopy prior to implantation of deep brain-stimulating electrodes in awake patients. The neural elements affected by such microstimulation are unknown. Using paraesthesia as the behavioural-physiological response threshold, we measured chronaxie times for microstimuli applied to both somatosensory thalamic nuclei (cellular region) and its axonal afferents, the medial lemniscus. White matter chronaxie times were relatively unimodal, whereas two different clusters of chronaxie times were identified in grey matter: one corresponding to that of the medial lemniscus and the other about five times longer and compatible with that obtained from cell somata. Therefore, excitations of local axons and/or cell bodies can both contribute to the paraesthesia evoked during intra-operative thalamic mapping.

Original languageEnglish (US)
Pages (from-to)728-732
Number of pages5
JournalEuropean Journal of Neuroscience
Volume18
Issue number3
DOIs
StatePublished - Aug 2003
Externally publishedYes

Fingerprint

Chronaxy
Paresthesia
Thalamus
Electrodes
Thalamic Nuclei
Body Regions
Carisoprodol
Axons
Brain

Keywords

  • Chronaxie time
  • Micro-electrode recordings
  • Microstimulation
  • Neural elements
  • Paraesthesia
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neural substrates of microstimulation-evoked tingling : A chronaxie study in human somatosensory thalamus. / Kiss, Zelma H T; Anderson, Trent R; Hansen, Terry; Kirstein, Dolen; Suchowersky, Oksana; Hu, Bin.

In: European Journal of Neuroscience, Vol. 18, No. 3, 08.2003, p. 728-732.

Research output: Contribution to journalArticle

Kiss, Zelma H T ; Anderson, Trent R ; Hansen, Terry ; Kirstein, Dolen ; Suchowersky, Oksana ; Hu, Bin. / Neural substrates of microstimulation-evoked tingling : A chronaxie study in human somatosensory thalamus. In: European Journal of Neuroscience. 2003 ; Vol. 18, No. 3. pp. 728-732.
@article{d9c29eeaa48e4aa7934d15de2e257d96,
title = "Neural substrates of microstimulation-evoked tingling: A chronaxie study in human somatosensory thalamus",
abstract = "Intra-operative micro-electrode stimulation of sensorimotor thalamus produces paraesthesia or tingling in various body regions and is used to map somatotopy prior to implantation of deep brain-stimulating electrodes in awake patients. The neural elements affected by such microstimulation are unknown. Using paraesthesia as the behavioural-physiological response threshold, we measured chronaxie times for microstimuli applied to both somatosensory thalamic nuclei (cellular region) and its axonal afferents, the medial lemniscus. White matter chronaxie times were relatively unimodal, whereas two different clusters of chronaxie times were identified in grey matter: one corresponding to that of the medial lemniscus and the other about five times longer and compatible with that obtained from cell somata. Therefore, excitations of local axons and/or cell bodies can both contribute to the paraesthesia evoked during intra-operative thalamic mapping.",
keywords = "Chronaxie time, Micro-electrode recordings, Microstimulation, Neural elements, Paraesthesia, Thalamus",
author = "Kiss, {Zelma H T} and Anderson, {Trent R} and Terry Hansen and Dolen Kirstein and Oksana Suchowersky and Bin Hu",
year = "2003",
month = "8",
doi = "10.1046/j.1460-9568.2003.02793.x",
language = "English (US)",
volume = "18",
pages = "728--732",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Neural substrates of microstimulation-evoked tingling

T2 - A chronaxie study in human somatosensory thalamus

AU - Kiss, Zelma H T

AU - Anderson, Trent R

AU - Hansen, Terry

AU - Kirstein, Dolen

AU - Suchowersky, Oksana

AU - Hu, Bin

PY - 2003/8

Y1 - 2003/8

N2 - Intra-operative micro-electrode stimulation of sensorimotor thalamus produces paraesthesia or tingling in various body regions and is used to map somatotopy prior to implantation of deep brain-stimulating electrodes in awake patients. The neural elements affected by such microstimulation are unknown. Using paraesthesia as the behavioural-physiological response threshold, we measured chronaxie times for microstimuli applied to both somatosensory thalamic nuclei (cellular region) and its axonal afferents, the medial lemniscus. White matter chronaxie times were relatively unimodal, whereas two different clusters of chronaxie times were identified in grey matter: one corresponding to that of the medial lemniscus and the other about five times longer and compatible with that obtained from cell somata. Therefore, excitations of local axons and/or cell bodies can both contribute to the paraesthesia evoked during intra-operative thalamic mapping.

AB - Intra-operative micro-electrode stimulation of sensorimotor thalamus produces paraesthesia or tingling in various body regions and is used to map somatotopy prior to implantation of deep brain-stimulating electrodes in awake patients. The neural elements affected by such microstimulation are unknown. Using paraesthesia as the behavioural-physiological response threshold, we measured chronaxie times for microstimuli applied to both somatosensory thalamic nuclei (cellular region) and its axonal afferents, the medial lemniscus. White matter chronaxie times were relatively unimodal, whereas two different clusters of chronaxie times were identified in grey matter: one corresponding to that of the medial lemniscus and the other about five times longer and compatible with that obtained from cell somata. Therefore, excitations of local axons and/or cell bodies can both contribute to the paraesthesia evoked during intra-operative thalamic mapping.

KW - Chronaxie time

KW - Micro-electrode recordings

KW - Microstimulation

KW - Neural elements

KW - Paraesthesia

KW - Thalamus

UR - http://www.scopus.com/inward/record.url?scp=0041378190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041378190&partnerID=8YFLogxK

U2 - 10.1046/j.1460-9568.2003.02793.x

DO - 10.1046/j.1460-9568.2003.02793.x

M3 - Article

VL - 18

SP - 728

EP - 732

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 3

ER -