Neurochemical challenge

Michael L. Heien, Jonathan V. Sweedler

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The effect of neurotransmitters on the firing pattern of the postsynaptic cells with which the new neuronal type forms a synapse was investigated. Two sensors capable of detecting the different neurotransmitters which is an electrochemical sensor for neurotransmitter A and a cannula interfaced with capillary electrophoresis for detection of neurotransmitter B was developed. To determine the biological function of the neurotransmitter the electrical output of the circuit as a response to an input stimulus was measured. The detection limit of neurotransmitter A was limited to 40 nmol L-1 and the detection limit of the neurotransmitter B was 80 nmol L-1. the closest position of the dual sensor was approximately 5 μm from the synapse.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalAnalytical and bioanalytical chemistry
Volume387
Issue number1
DOIs
StatePublished - Jan 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry

Fingerprint Dive into the research topics of 'Neurochemical challenge'. Together they form a unique fingerprint.

  • Cite this