Neurochemical challenge

Michael L Heien, Jonathan V. Sweedler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of neurotransmitters on the firing pattern of the postsynaptic cells with which the new neuronal type forms a synapse was investigated. Two sensors capable of detecting the different neurotransmitters which is an electrochemical sensor for neurotransmitter A and a cannula interfaced with capillary electrophoresis for detection of neurotransmitter B was developed. To determine the biological function of the neurotransmitter the electrical output of the circuit as a response to an input stimulus was measured. The detection limit of neurotransmitter A was limited to 40 nmol L-1 and the detection limit of the neurotransmitter B was 80 nmol L-1. the closest position of the dual sensor was approximately 5 μm from the synapse.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalAnalytical and Bioanalytical Chemistry
Volume387
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

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Neurotransmitter Agents
Synapses
Limit of Detection
Capillary electrophoresis
Electrochemical sensors
Sensors
Capillary Electrophoresis
Networks (circuits)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Clinical Biochemistry

Cite this

Neurochemical challenge. / Heien, Michael L; Sweedler, Jonathan V.

In: Analytical and Bioanalytical Chemistry, Vol. 387, No. 1, 01.2007, p. 3-4.

Research output: Contribution to journalArticle

Heien, Michael L ; Sweedler, Jonathan V. / Neurochemical challenge. In: Analytical and Bioanalytical Chemistry. 2007 ; Vol. 387, No. 1. pp. 3-4.
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