Neuroendocrine Aging: Hypothalamic-Pituitary-Gonadal Axis in Women

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Menopause constitutes one of the most dramatic and consistent aging changes in humans. The hallmark of reproductive aging is degeneration of ovarian follicles, which accelerates during the fourth decade of life. The earliest hormone marker of reproductive aging is elevated serum follicle-stimulating hormone, which is inversely correlated with inhibin B secretion from developing follicles. A prolonged menopausal transition, characterized by irregular cycles and fluctuating hormone levels, is followed by the cessation of reproductive cycles. In the postmenopausal period, the reproductive neuroendocrine axis is strongly influenced by the withdrawal of the negative feedback effects of ovarian hormones. In addition, there is evidence of aging of the hypothalamic-pituitary axis in women that is independent from the changes in gonadal status.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages291-297
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

Fingerprint

Hormones
Postmenopause
Ovarian Follicle
Follicle Stimulating Hormone
Menopause
Serum
inhibin B

Keywords

  • Estrogen
  • FSH
  • GnRH
  • Gonadal feedback
  • Hypothalamus
  • Inhibin
  • LH
  • Menopause
  • Neuroendocrine
  • Neurokinin B
  • Ovary
  • Reproduction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neuroendocrine Aging : Hypothalamic-Pituitary-Gonadal Axis in Women. / Rance, Naomi E.

Encyclopedia of Neuroscience. Elsevier Ltd, 2010. p. 291-297.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rance, Naomi E. / Neuroendocrine Aging : Hypothalamic-Pituitary-Gonadal Axis in Women. Encyclopedia of Neuroscience. Elsevier Ltd, 2010. pp. 291-297
@inbook{edc6db2862f0473d963fc31b689a22e0,
title = "Neuroendocrine Aging: Hypothalamic-Pituitary-Gonadal Axis in Women",
abstract = "Menopause constitutes one of the most dramatic and consistent aging changes in humans. The hallmark of reproductive aging is degeneration of ovarian follicles, which accelerates during the fourth decade of life. The earliest hormone marker of reproductive aging is elevated serum follicle-stimulating hormone, which is inversely correlated with inhibin B secretion from developing follicles. A prolonged menopausal transition, characterized by irregular cycles and fluctuating hormone levels, is followed by the cessation of reproductive cycles. In the postmenopausal period, the reproductive neuroendocrine axis is strongly influenced by the withdrawal of the negative feedback effects of ovarian hormones. In addition, there is evidence of aging of the hypothalamic-pituitary axis in women that is independent from the changes in gonadal status.",
keywords = "Estrogen, FSH, GnRH, Gonadal feedback, Hypothalamus, Inhibin, LH, Menopause, Neuroendocrine, Neurokinin B, Ovary, Reproduction",
author = "Rance, {Naomi E}",
year = "2010",
doi = "10.1016/B978-008045046-9.00115-7",
language = "English (US)",
isbn = "9780080450469",
pages = "291--297",
booktitle = "Encyclopedia of Neuroscience",
publisher = "Elsevier Ltd",

}

TY - CHAP

T1 - Neuroendocrine Aging

T2 - Hypothalamic-Pituitary-Gonadal Axis in Women

AU - Rance, Naomi E

PY - 2010

Y1 - 2010

N2 - Menopause constitutes one of the most dramatic and consistent aging changes in humans. The hallmark of reproductive aging is degeneration of ovarian follicles, which accelerates during the fourth decade of life. The earliest hormone marker of reproductive aging is elevated serum follicle-stimulating hormone, which is inversely correlated with inhibin B secretion from developing follicles. A prolonged menopausal transition, characterized by irregular cycles and fluctuating hormone levels, is followed by the cessation of reproductive cycles. In the postmenopausal period, the reproductive neuroendocrine axis is strongly influenced by the withdrawal of the negative feedback effects of ovarian hormones. In addition, there is evidence of aging of the hypothalamic-pituitary axis in women that is independent from the changes in gonadal status.

AB - Menopause constitutes one of the most dramatic and consistent aging changes in humans. The hallmark of reproductive aging is degeneration of ovarian follicles, which accelerates during the fourth decade of life. The earliest hormone marker of reproductive aging is elevated serum follicle-stimulating hormone, which is inversely correlated with inhibin B secretion from developing follicles. A prolonged menopausal transition, characterized by irregular cycles and fluctuating hormone levels, is followed by the cessation of reproductive cycles. In the postmenopausal period, the reproductive neuroendocrine axis is strongly influenced by the withdrawal of the negative feedback effects of ovarian hormones. In addition, there is evidence of aging of the hypothalamic-pituitary axis in women that is independent from the changes in gonadal status.

KW - Estrogen

KW - FSH

KW - GnRH

KW - Gonadal feedback

KW - Hypothalamus

KW - Inhibin

KW - LH

KW - Menopause

KW - Neuroendocrine

KW - Neurokinin B

KW - Ovary

KW - Reproduction

UR - http://www.scopus.com/inward/record.url?scp=84882878408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882878408&partnerID=8YFLogxK

U2 - 10.1016/B978-008045046-9.00115-7

DO - 10.1016/B978-008045046-9.00115-7

M3 - Chapter

AN - SCOPUS:84882878408

SN - 9780080450469

SP - 291

EP - 297

BT - Encyclopedia of Neuroscience

PB - Elsevier Ltd

ER -