Neuroendocrine aging: Hypothalamic-pituitary-gonadal axis in women

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Reproductive aging in women is characterized by degeneration of ovarian follicles. After a transition phase, the final menstrual period marks beginning of the postmenopausal period. Estrogen withdrawal in postmenopausal women results in elevated hypothalamic GnRH secretion resulting in increased gonadotropin secretion from the anterior pituitary gland. In the hypothalamus of postmenopausal women, there is an increase in kisspeptin and neurokinin B gene expression in a subpopulation of neurons known as KNDy (kisspeptin/neurokinin B/dynorphin) neurons. KNDy neurons are a site of steroid negative feedback, are regulators of pulsatile GnRH secretion and may even contribute to the generation of hot flushes.

Original languageEnglish (US)
Title of host publicationThe Curated Reference Collection in Neuroscience and Biobehavioral Psychology
PublisherElsevier Science Ltd.
Pages291-297
Number of pages7
ISBN (Electronic)9780128093245
DOIs
StatePublished - Jan 1 2016

Keywords

  • Dynorphin
  • Estrogen
  • FSH
  • GnRH
  • Gonadal feedback
  • Hypothalamus
  • Inhibin
  • Kisspeptin
  • LH
  • Menopause
  • Neuroendocrine
  • Neurokinin B
  • Ovary
  • Reproduction

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Rance, N. E. (2016). Neuroendocrine aging: Hypothalamic-pituitary-gonadal axis in women. In The Curated Reference Collection in Neuroscience and Biobehavioral Psychology (pp. 291-297). Elsevier Science Ltd.. https://doi.org/10.1016/B978-0-12-809324-5.02232-X