Neurokinin A receptors are coupled to calcium mobilization in transfected fibroblasts

Alden K. Henderson, Henry I. Yamamura, Carlo A. Maggi, William R Roeske, Thomas L. Smith

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neurokinin A (NKA) mediated a concentration dependent increase in the intracellular free Ca2+ concentration, [Ca2+]i, in B82 fibroblasts transfected with the neurokinin 2 (NK2) receptor. The EC50 value of this response was 24 nM. A selective NK2 antagonist, MEN 10207, at a concentration of 1 μM completely inhibited the [Ca2+]i rise to 0.1 μM NKA. These results suggest that activation of NK2 receptors expressed in the transfected fibroblasts are functionally coupled to intracellular calcium mobilization.

Original languageEnglish (US)
Pages (from-to)251-253
Number of pages3
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume206
Issue number3
DOIs
StatePublished - Mar 25 1991

Fingerprint

Neurokinin-2 Receptors
Neurokinin A
Fibroblasts
Calcium

Keywords

  • Ca mobilization
  • Fluo-3, AM
  • Neurokinin A (NKA)
  • NK receptor
  • Transfected fibroblast

ASJC Scopus subject areas

  • Pharmacology

Cite this

Neurokinin A receptors are coupled to calcium mobilization in transfected fibroblasts. / Henderson, Alden K.; Yamamura, Henry I.; Maggi, Carlo A.; Roeske, William R; Smith, Thomas L.

In: European Journal of Pharmacology: Molecular Pharmacology, Vol. 206, No. 3, 25.03.1991, p. 251-253.

Research output: Contribution to journalArticle

Henderson, Alden K. ; Yamamura, Henry I. ; Maggi, Carlo A. ; Roeske, William R ; Smith, Thomas L. / Neurokinin A receptors are coupled to calcium mobilization in transfected fibroblasts. In: European Journal of Pharmacology: Molecular Pharmacology. 1991 ; Vol. 206, No. 3. pp. 251-253.
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