Neurokinin A receptors are coupled to calcium mobilization in transfected fibroblasts

Alden K. Henderson, Henry I. Yamamura, Carlo A. Maggi, William R. Roeske, Thomas L. Smith

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Neurokinin A (NKA) mediated a concentration dependent increase in the intracellular free Ca2+ concentration, [Ca2+]i, in B82 fibroblasts transfected with the neurokinin 2 (NK2) receptor. The EC50 value of this response was 24 nM. A selective NK2 antagonist, MEN 10207, at a concentration of 1 μM completely inhibited the [Ca2+]i rise to 0.1 μM NKA. These results suggest that activation of NK2 receptors expressed in the transfected fibroblasts are functionally coupled to intracellular calcium mobilization.

Original languageEnglish (US)
Pages (from-to)251-253
Number of pages3
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume206
Issue number3
DOIs
StatePublished - Mar 25 1991

Keywords

  • Ca mobilization
  • Fluo-3, AM
  • NK receptor
  • Neurokinin A (NKA)
  • Transfected fibroblast

ASJC Scopus subject areas

  • Pharmacology

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