Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2

Niroshika Keppetipola, Shalini Sharma, Qin Li, Douglas L. Black

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations

Abstract

Alternative splicing patterns are regulated by RNA binding proteins that assemble onto each pre-mRNA to form a complex RNP structure. The polypyrimidine tract binding protein, PTB, has served as an informative model for understanding how RNA binding proteins affect spliceosome assembly and how changes in the expression of these proteins can control complex programs of splicing in tissues. In this review, we describe the mechanisms of splicing regulation by PTB and its function, along with its paralog PTBP2, in neuronal development.

Original languageEnglish (US)
Pages (from-to)360-378
Number of pages19
JournalCritical reviews in biochemistry and molecular biology
Volume47
Issue number4
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • Alternative splicing
  • Neuronal development
  • RNA binding protein
  • RNP
  • Spliceosome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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