Neuropeptides and peptide hormones in Anopheles gambiae

Michael A. Riehle, Stephen F. Garczynski, Joe W. Crim, Catherine A. Hill, Mark R. Brown

Research output: Contribution to journalArticle

227 Scopus citations

Abstract

The African malaria mosquito, Anopheles gambiae, is specialized for rapid completion of development and reproduction. A vertebrate blood meal is required for egg production, and multiple feedings subsequently allow transmission of malaria parasites, Plasmodium spp. Regulatory peptides from 35 genes annotated from the A. gambiae genome likely coordinate these and other physiological processes. Plasmodium parasites may affect actions of newly identified insulin-like peptides, which coordinate growth and reproduction of its vector, A. gambiae, as in Drosophila melanogaster, Caenorhabditis elegans, and mammals. This genomic information provides a basis to expand understanding of hematophagy and pathogen transmission in this mosquito.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
JournalScience
Volume298
Issue number5591
DOIs
StatePublished - Oct 4 2002

ASJC Scopus subject areas

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    Riehle, M. A., Garczynski, S. F., Crim, J. W., Hill, C. A., & Brown, M. R. (2002). Neuropeptides and peptide hormones in Anopheles gambiae. Science, 298(5591), 172-175. https://doi.org/10.1126/science.1076827