Neuropeptides Internalization

J. M. Jimenez-Andrade, P. W. Mantyh

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Substance P belongs to a group of neuropeptides known as the neurokinins (NKs). The biological effects of substance P in the central nervous system are mediated primarily by its binding to the NK-1 receptor. The NK-1 receptor is distributed in the plasma membrane of unstimulated cells and upon stimulation undergoes rapid internalization, followed by rapid recycling to the plasma membrane. Studies examining internalization of this neuropeptide-receptor complex have provided insights into when neuropeptides are activated in health and disease and have allowed the selective delivery of high-molecular weight therapies to the intracellular compartment of neuropeptide receptor-expressing cells.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Pages867-871
Number of pages5
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009
Externally publishedYes

Keywords

  • Affective behaviors
  • Depression
  • Endocytosis
  • Pain
  • Spinal cord
  • Substance P

ASJC Scopus subject areas

  • Neuroscience(all)

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