Neuroprotective agents for the treatment of acute ischemic stroke

Bruce Ovbiagele, Chelsea S. Kidwell, Sidney Starkman, Jeffrey L. Saver

Research output: Contribution to journalReview article

93 Scopus citations

Abstract

Neuroprotective treatments are therapies designed to interrupt the cellular, biochemical, and metabolic elaboration of injury during or following exposure to ischemia; they encompass a rapidly expanding array of pharmacologic interventions. Various classes of neuroprotective agents have reached phase III efficacy trials in focal ischemic stroke, but none has proven effective, despite successful preceding animal studies. This notwithstanding, recent favorable results of hypothermia in human cardiac arrest trials have validated the general concept of neuroprotection. In addition, the promise of neuroprotective therapy for focal acute ischemic stroke has been renewed by innovations in strategies of preclinical drug development and clinical trial design that rectify past defects, including trial testing of combination therapies rather than single agents and novel approaches to accelerating time to initiation of experimental treatment.

Original languageEnglish (US)
Pages (from-to)9-20
Number of pages12
JournalCurrent Neurology and Neuroscience Reports
Volume3
Issue number1
DOIs
StatePublished - Jan 2003
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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