Neuropsychological, behavioral, and anatomical evolution in right temporal variant frontotemporal dementia: A longitudinal and post-mortem single case analysis

Maya L. Henry, Stephen M. Wilson, Jennifer M. Ogar, Manu S. Sidhu, Katherine P. Rankin, Tatiana Cattaruzza, Bruce L. Miller, Maria Luisa Gorno-Tempini, William W. Seeley

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

We describe a patient with semantic variant of frontotemporal dementia who received longitudinal clinical evaluations and structural MRI scans and subsequently came to autopsy. She presented with early behavior changes and semantic loss for foods and people and ultimately developed a pervasive semantic impairment affecting social-emotional as well as linguistic domains. Imaging revealed predominant atrophy of the right temporal lobe, with later involvement of the left, and pathology confirmed bilateral temporal involvement. Findings support the view that left and right anterior temporal lobes serve as semantic hubs that may be affected differentially in semantic variant by early, relatively unilateral damage.

Original languageEnglish (US)
Pages (from-to)100-109
Number of pages10
JournalNeurocase
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Frontotemporal dementia
  • Right temporal variant of FTD
  • Semantic dementia
  • TDP-43
  • Temporal lobe

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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    Henry, M. L., Wilson, S. M., Ogar, J. M., Sidhu, M. S., Rankin, K. P., Cattaruzza, T., Miller, B. L., Gorno-Tempini, M. L., & Seeley, W. W. (2014). Neuropsychological, behavioral, and anatomical evolution in right temporal variant frontotemporal dementia: A longitudinal and post-mortem single case analysis. Neurocase, 20(1), 100-109. https://doi.org/10.1080/13554794.2012.732089