Neuropsychological differentiation of late onset schizophrenia and frontotemporal dementia

K. K. Zakzanis, A. Kielar, D. A. Young, M. Boulos

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Frontaltemporal dementia (FTD) and schizophrenia are characterised by disturbances in cognition, personality, behaviour, and social functioning often leading to a decline in activities in daily living. Deterioration of comportment and disturbances in attention are typical in both disorders and manifest behaviourally in terms of withdrawal, isolation, lack of volition, emotional unresponsiveness, and poverty of speech. Accordingly, the considerable overlap in behavioural expression between patients with schizophrenia and FTD makes a differential diagnosis difficult. This different diagnosis is especially difficult when the age of onset of schizophrenia is late (i.e., 45 +). The purpose of this study was to identify which neuropsychological tests best differentiate patients with late onset schizophrenia from patients with FTD. Hence, neurocognitive test results from a total of 12 patients with FTD and 32 patients with schizophrenia were analysed using test sensitivity statistics (i.e., Cohen's U2% overlap). The results support a test battery composed of the WAIS-R Vocabulary, Information, Digit Span, and Comprehension subtests, and the Hooper Visual Organisation test as being the most sensitive measures to diagnostic differentiation between patients with FTD and those with late onset schizophrenia.

Original languageEnglish (US)
Pages (from-to)63-77
Number of pages15
JournalCognitive Neuropsychiatry
Volume6
Issue number1
DOIs
StatePublished - Feb 20 2001
Externally publishedYes

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Frontotemporal Dementia
Schizophrenia
Dementia
Vocabulary
Neuropsychological Tests
Poverty
Activities of Daily Living
Age of Onset
Cognition
Personality
Differential Diagnosis
Organizations

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

Neuropsychological differentiation of late onset schizophrenia and frontotemporal dementia. / Zakzanis, K. K.; Kielar, A.; Young, D. A.; Boulos, M.

In: Cognitive Neuropsychiatry, Vol. 6, No. 1, 20.02.2001, p. 63-77.

Research output: Contribution to journalArticle

Zakzanis, K. K. ; Kielar, A. ; Young, D. A. ; Boulos, M. / Neuropsychological differentiation of late onset schizophrenia and frontotemporal dementia. In: Cognitive Neuropsychiatry. 2001 ; Vol. 6, No. 1. pp. 63-77.
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