Neurotensin-like immunoreactivity and neurotensin receptors in the rat hypothalamus and in the neurointermediate lobe of the pituitary gland

M. Goedert, S. L. Lightman, P. W. Mantyh, S. P. Hunt, P. C. Emson

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

In the rat hypothalamus, cell bodies containing neurotensin-like immunoreactivity were mainly found in the medial preoptic area, the periventricular nucleus, the paraventricular nucleus, the supraoptic nucleus and the arcuate nucleus. [3H]neurotensin binding sites were observed throughout the hypothalamus with a dense accumulation of silver grains over the paraventricular nucleus, the arcuate nucleus and the median eminence region. By radioimmunoassay neurotensin-like immunoreactivity was also found in the neurointermediate lobe of the pituitary gland of various mammalian species and in human postmortem posterior pituitary glands. In the rat studies involving pituitary stalk transections and the neurotoxin monosodium glutamate indicated the presence of a neurotensinergic pathway from the arcuate nucleus to the neurointermediate lobe of the pituitary gland. [3H]neurotensin binding sites were found to be concentrated over the intermediate lobe of the pituitary gland and their presence was not affected by pituitary stalk transection, indicating their localization on endocrine cells of the intermediate lobe of the pituitary gland.

Original languageEnglish (US)
Pages (from-to)59-69
Number of pages11
JournalBrain Research
Volume358
Issue number1-2
DOIs
StatePublished - Dec 9 1985
Externally publishedYes

Keywords

  • hypothalamus
  • monosodium glutamate
  • neurointermediate pituitary gland
  • neurotensin receptor
  • neurotensin-like immunoreactivity
  • pituitary stalk transection

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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