Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices

M. Goedert, R. D. Pinnock, C. P. Downes, P. W. Mantyh, P. C. Emson

Research output: Contribution to journalArticlepeer-review

94 Scopus citations

Abstract

Neurotensin stimulated inositol phosphilipid hydrolysis in matched coronal vibratome sections through the rat brain. This effect was tetrodotoxin-resistant and a good correlation was noticed between the magnitude of neurotensin-stimulated inositol phospholipid hydrolysis and the number of specific [3H]neurotensin binding sites in various brain regions. Neurotensin produced no significant effect on either basal or stimulated cAMP levels.

Original languageEnglish (US)
Pages (from-to)193-197
Number of pages5
JournalBrain Research
Volume323
Issue number1
DOIs
StatePublished - Dec 3 1984
Externally publishedYes

Keywords

  • cAMP
  • inositol phospholipid hydrolysis
  • neurotensin
  • second messengers

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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